2. Signaling Pathways
  3. Epigenetics
  4. YTHDF

YTHDF

(YTH) domain-containing family proteins (YTHDF)

(YTH) domain-containing family proteins (YTHDFs) are a class of cytoplasmic m6A-binding proteins characterized by the vertebrate YTH domain, which enables them to regulate RNA fate extensively. The YTH domain serves as the basis for specific recognition of m6A-modified RNA. As the most studied "readers" of m6A, the YTHDF family includes YTHDF1, YTHDF2, and YTHDF3. YTHDF1 promotes RNA translation, while YTHDF2 facilitates RNA decay. YTHDF3 exhibits a dual function that depends on its binding partner. Upon entering the cytoplasm, m6A-modified mRNAs are initially bound by YTHDF3 or a YTHDF3-YTHDF1 complex, followed by recognition by YTHDF2, thereby directing the diverse fates of the targeted mRNA. The YTHDF family plays a significant role in mediating tumor proliferation, metastasis, metabolism, drug resistance, and immunity. Moreover, they possess potential as predictive and therapeutic biomarkers[1].

YTHDF Isoform Specific Products:

YTHDF Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154919
    DC-Y13-27
    		Inhibitor 99.52%
    DC-Y13-27, a derivative of DC-Y13, is a YTHDF2 inhibitor (KD: 37.9 μM). DC-Y13-27 enhances tumor responses to radiotherapy and immunotherapy.
    DC-Y13-27
  • HY-137341
    SK-3-91
    		Degrader 98.47%
    SK-3-91 is a PROTAC-type multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). SK-3-91 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway. SK-3-91 degrades YTHDF2. SK-3-91 inhibits cell proliferation and induces morphological changes. (Pink: TAE648 ligand (HY-169396); Blue: E3 ligase ligand (HY-131717); Black: Linker (HY-140819). The E3 ligase ligand and linker can form a conjugate (HY-169397)).
    SK-3-91
  • HY-RS15939
    YTHDF3 Human Pre-designed siRNA Set A
    		Inhibitor

    YTHDF3 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    YTHDF3 Human Pre-designed siRNA Set A
    YTHDF3 Human Pre-designed siRNA Set A
  • HY-RS15937
    YTHDF1 Human Pre-designed siRNA Set A
    		Inhibitor

    YTHDF1 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    YTHDF1 Human Pre-designed siRNA Set A
    YTHDF1 Human Pre-designed siRNA Set A
  • HY-173008
    YTHDF2-IN-1
    		Inhibitor
    YTHDF2-IN-1 (Compound CK-75) is the inhibitor for YT521-B homology domain family 2 YTHDF2 (Kd=26.2 μM), that blocks the interaction between YTHDF2 and m6A RNA. YTHDF2-IN-1 inhibits the colony formation of JAR cells, exhibits antiproliferative activity in a variety of cancer cells (IC50 in micromolar levels), arrests the cell cycle at G0/G1 phase, induces apoptosis in K562.
    YTHDF2-IN-1
  • HY-168610
    YTH-IN-1
    		Inhibitor
    YTH-IN-1 (compound N-7) is a pan-YTH domain inhibitor with the IC50 values of 39 μM, 34 μM, 35 μM, 48 μM and 30 μM for human YTHYTHDF1, YTHYTHDF2, YTHYTHDF3, YTHYTHDC1, and YTHYTHDC2, respectively.
    YTH-IN-1
  • HY-RS15938
    YTHDF2 Human Pre-designed siRNA Set A
    		Inhibitor

    YTHDF2 Human Pre-designed siRNA Set A contains three designed siRNAs for YTHDF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    YTHDF2 Human Pre-designed siRNA Set A
    YTHDF2 Human Pre-designed siRNA Set A
YTHDF Isoform Comparison

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