NNMT-IN-6 hydrochloride

Name: NNMT-IN-6 hydrochloride
Brand: MedChemExpress
SKU: HY-138993A
Rating: 4.5 (1 reviews)

Cat. No.: HY-138993A: FAQs
Data Sheet Handling Instructions Technical Support

NNMT-IN-6 hydrochloride (compound 78) is a potent nicotinamide N-methyltransferase (NNMT) inhibitor with an IC₅₀ of 1.41 μM and a K_d of 5.6 μM. NNMT-IN-6 hydrochloride shows an inhibitory effect on the cell proliferation of the HSC-2 human oral cancer cell line.

For research use only. We do not sell to patients.

NNMT-IN-6 hydrochloride Chemical Structure

CAS No. : 3031756-18-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of NNMT-IN-6 hydrochloride:

NNMT-IN-6 Get quote

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NNMT

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

544.00

Formula

C₂₅H₃₀ClN₇O₅

CAS No.

3031756-18-7

Appearance

Solid

SMILES

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](CN(CC(C=C4)=CC5=C4C=CC=C5)CC[C@@H](C(O)=O)N)O3.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (459.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 250 mg/mL (459.56 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.8382 mL	9.1912 mL	18.3824 mL
5 mM	0.3676 mL	1.8382 mL	3.6765 mL
10 mM	0.1838 mL	0.9191 mL	1.8382 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gao Y, et al. Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity. J Med Chem. 2019 Jul 25;62(14):6597-6614. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	1.8382 mL	9.1912 mL	18.3824 mL	45.9559 mL
	5 mM	0.3676 mL	1.8382 mL	3.6765 mL	9.1912 mL
	10 mM	0.1838 mL	0.9191 mL	1.8382 mL	4.5956 mL
	15 mM	0.1225 mL	0.6127 mL	1.2255 mL	3.0637 mL
	20 mM	0.0919 mL	0.4596 mL	0.9191 mL	2.2978 mL
	25 mM	0.0735 mL	0.3676 mL	0.7353 mL	1.8382 mL
	30 mM	0.0613 mL	0.3064 mL	0.6127 mL	1.5319 mL
	40 mM	0.0460 mL	0.2298 mL	0.4596 mL	1.1489 mL
	50 mM	0.0368 mL	0.1838 mL	0.3676 mL	0.9191 mL
	60 mM	0.0306 mL	0.1532 mL	0.3064 mL	0.7659 mL
	80 mM	0.0230 mL	0.1149 mL	0.2298 mL	0.5744 mL
	100 mM	0.0184 mL	0.0919 mL	0.1838 mL	0.4596 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.