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  4. JBSNF-000028 TFA

JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders.

For research use only. We do not sell to patients.

JBSNF-000028 TFA Chemical Structure

JBSNF-000028 TFA Chemical Structure

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5 mg USD 360 In-stock
10 mg USD 570 In-stock
25 mg USD 1150 In-stock
50 mg USD 1840 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of JBSNF-000028 TFA:

JBSNF-000028 TFA Related Antibodies

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Description

JBSNF-000028 TFA is an orally active nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 0.033 μM, 0.19 μM and 0.21 μM against human NNMT (hNNMT), monkey NNMT (mkNNMT), and mouse NNMT (mNNMT), respectively. JBSNF-000028 TFA can be used for the research of metabolic disorders[1].

IC50 & Target

IC50: 0.033 μM (hNNMT), 0.19 μM (mkNNMT), 0.21 μM (mNNMT)[1]
In Vitro

JBSNF-000028 TFA (24 h) inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells[1].
JBSNF-000028 TFA (10-100 μM; 72 h) has no cytotoxicity against HepG2 cells[1].
JBSNF-000028 TFA binds below a hairpin structural motif at the nicotinamide pocket and stacks between Tyr-204 (from Hairpin) and Leu-164 (from central domain)[1].
JBSNF-000028 TFA is inactive against a broad panel of targets related to metabolism and safety[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JBSNF-000028 TFA Related Antibodies
In Vivo

JBSNF-000028 TFA (50 mg/kg; p.o.; twice daily for 27 days) improves glucose and lipid handling in mice with diet-induced obesity (DIO)[1].
JBSNF-000028 TFA (50 mg/kg; p.o.; twice daily for 4 weeks) improves glucose tolerance in NNMT knockout mice with diet-induced obesity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

301.26

Formula

C13H14F3N3O2
Appearance

Solid

Color

White to off-white

SMILES

CN1CC2=C3C(CCN3C1=N)=CC=C2.FC(F)(C(O)=O)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (331.94 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3194 mL 16.5970 mL 33.1939 mL
5 mM 0.6639 mL 3.3194 mL 6.6388 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3194 mL 16.5970 mL 33.1939 mL 82.9848 mL
5 mM 0.6639 mL 3.3194 mL 6.6388 mL 16.5970 mL
10 mM 0.3319 mL 1.6597 mL 3.3194 mL 8.2985 mL
15 mM 0.2213 mL 1.1065 mL 2.2129 mL 5.5323 mL
20 mM 0.1660 mL 0.8298 mL 1.6597 mL 4.1492 mL
25 mM 0.1328 mL 0.6639 mL 1.3278 mL 3.3194 mL
30 mM 0.1106 mL 0.5532 mL 1.1065 mL 2.7662 mL
40 mM 0.0830 mL 0.4149 mL 0.8298 mL 2.0746 mL
50 mM 0.0664 mL 0.3319 mL 0.6639 mL 1.6597 mL
60 mM 0.0553 mL 0.2766 mL 0.5532 mL 1.3831 mL
80 mM 0.0415 mL 0.2075 mL 0.4149 mL 1.0373 mL
100 mM 0.0332 mL 0.1660 mL 0.3319 mL 0.8298 mL
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JBSNF-000028 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JBSNF-000028JBSNF000028JBSNF 000028Otherstype 2 diabetesliver diseasesnicotinamide N-methyltransferaseNNMTInhibitorinhibitorinhibit

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