2. Signaling Pathways
  3. Autophagy
    PROTAC
  4. ATTECs
  5. ATTECs Degrader

ATTECs Degrader

ATTECs Degraders (2):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-162588
    MC-ND-18
    MC-ND-18 is an ATTEC degrader of NLRP3 through autophagic mechanisms, with the DC50 of 125.5 nM in THP-1 cell. MC-ND-18 is composed of a NLRP3 ligand, linker and LC3 ligand.
    MC-ND-18
  • HY-162540
    LLC355
    LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion.
    LLC355