2. Signaling Pathways
  3. Autophagy
    PROTAC
  4. ATTECs
  5. ATTECs Degrader

ATTECs Degrader

ATTECs Degraders (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-162588
    MC-ND-18
    MC-ND-18 is an ATTEC degrader of NLRP3 through autophagic mechanisms, with the DC50 of 125.5 nM in THP-1 cell. MC-ND-18 is composed of a NLRP3 ligand, linker and LC3 ligand.
    MC-ND-18
  • HY-162540
    LLC355
    LLC355 is a discoidin domain receptor 1 (DDR1) ATTEC degrader. LLC355 efficiently degrades DDR1 protein with a DC50 value of 150.8 nM in non-small cell lung cancer NCI-H23 cells. LLC355 induces DDR1 degradation via lysosome-mediated autophagy. LLC355 potently inhibits cancer cell tumorigenicity, migration, and invasion.
    LLC355
  • HY-176130
    MRL828
    MRL828 combines a Tau pathology-binding ligand and modified guanine moiety based on the ATTEC technology to selectively designate aggregated tau proteins for clearance via the ALP. MRL828 decreases intracellular Tau aggregates and promotes the secretion of Tau.
    MRL828