2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Calmodulin

Calmodulin

Calmodulin; CaM; Calcium-Modulated Protein

Calmodulin is the highly conserved, calcium-sensitive protein, that acts as the calcium ion sensor in cells, Ca2+-dependently binds to target proteins, and converts Ca2+ concentrations into cellular signals. Calmodulin has four different Ca2+ binding sites named EF-hand for the sensing of Ca2+ signaling with different amplitude, duration, and location. Calmodulin dysfunction could lead to myocardial contractile problems, neuronal damage, or tumor angiogenesis dysregulation, which may cause cardiovascular diseases, neurological diseases, or cancer[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125449
    Fasciculic acid C
    		Antagonist
    Fasciculic acid C is a calmodulin antagonist that can be isolated from mushroom Naematoloma fasciculare.
    Fasciculic acid C
  • HY-106745
    Elziverine
    		Antagonist
    Elziverine (Ro 22-4839) is a brain circulation improvement agent with vasospasm antispasmodic effects. Elziverine is a calmodulin antagonist. Elziverine inhibits erythrocyte cell membrane rupture, platelet aggregation and lipid peroxidation.
    Elziverine
  • HY-137045
    Bisindolylmaleimide VII
    		Inhibitor
    Bisindolylmaleimide VII is a potent inhibitor of calmodulin with high affinity for calmodulin (Kd=186.2 nM). Bisindolylmaleimide VII is used to study the role of calmodulin in cancer, neurodegenerative diseases, and muscle dysfunction.
    Bisindolylmaleimide VII
  • HY-100263B
    Metofenazate (diethanesulfonate)
    		Inhibitor
    Metofenazate diethanesulfonate is a selective calmodulin inhibitor.
    Metofenazate (diethanesulfonate)
  • HY-107661R
    Arundic Acid (Standard)
    		Inhibitor
    Propiverine (hydrochloride) (Standard) is the analytical standard of Propiverine (hydrochloride). This product is intended for research and analytical applications. Propiverine hydrochloride is a bladder spasmolytic with calcium antagonistic and anticholinergic properties. Propiverine hydrochloride can be used for the research of overactive blaqdder and urinary incontinence.
    Arundic Acid (Standard)
Cat. No. Product Name / Synonyms Application Reactivity