2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Calmodulin
  5. Calmodulin Antagonist

Calmodulin Antagonist

Calmodulin Antagonists (17):

Cat. No. Product Name Effect Purity
  • HY-100912
    W-7 hydrochloride
    		Antagonist 99.96%
    W-7 hydrochloride is a selective calmodulin antagonist. W-7 hydrochloride inhibits the Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase with IC50 values of 28 μM and 51 μM, respectively. W-7 hydrochloride induces apoptosis and has antitumor activity.
  • HY-103319
    Calmidazolium chloride
    		Antagonist 99.69%
    Calmidazolium chloride (R 24571) is a calmodulin antagonist, antagonizing CaM-dependent phosphodiesterase and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase with IC50s of 0.15 and 0.35 μM, respectively. Also in anti-cancer research. Calmidazolium binds to calmodulin with a Kd of 3 nM.
  • HY-P1076A
    CALP2 TFA
    		Antagonist 99.79%
    CALP2 TFA is a calmodulin (CaM) antagonist (Kd of 7.9 µM) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 TFA inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 TFA potently inhibits of adhesion and degranulation. CALP2 TFA is also a strong activator of alveolar macrophages.
  • HY-100911
    W-5 hydrochloride
    		Antagonist 99.93%
    W-5 hydrochloride is a calmodulin antagonist. W-5 hydrochloride inhibits phosphodiesterase activation with an IC50 value of 240 µM. W-5 hydrochloride can be used as a negative control for W-7 (HY-100912).
  • HY-100913
    W-7 isomer hydrochloride
    		Antagonist 99.50%
    W-7 isomer hydrochloride is an isomer of W-7 hydrochloride (HY-100912). W-7 hydrochloride is a selective calmodulin antagonist.
  • HY-105118A
    Zaldaride maleate
    		Antagonist ≥98.0%
    Zaldaride maleate (CGS-9343B) is a potent, orally active and selective inhibitor of calmodulin. Zaldaride maleate inhibits CaM (calmodulin)-stimulated cAMP phosphodiesterase activity, with an IC50 of 3.3 nM. Zaldaride maleate prevents estrogen-induced transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in PC12 cells and inhibits nAChR.
  • HY-115745
    Calmodulin antagonist-1
    		Antagonist ≥98.0%
    Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=560 μM) in a competitive fashion with respect to cyclic GMP.
  • HY-100914
    A-7 hydrochloride
    		Antagonist 99.09%
    A-7 hydrochloride (Ophobolin A) is a calmodulin antagonist and can be used for the research of cancer.
  • HY-133782
    Fluphenazine-N-2-chloroethane hydrochloride
    		Antagonist
    Fluphenazine-N-2-chloroethane (SKF-7171A) hydrochloride is a potent irreversible calmodulin antagonist.
  • HY-P1076
    CALP2
    		Antagonist
    CALP2 is a calmodulin (CaM) antagonist ( (Kd of 7.9 µM)) with high affinity for binding to the CaM EF-hand/Ca2+-binding site. CALP2 inhibits CaM-dependent phosphodiesterase activity and increases intracellular Ca2+ concentrations. CALP2 potently inhibits of adhesion and degranulation. CALP2 is also a strong activator of alveolar macrophages.
  • HY-106645
    Cloxacepride
    		Antagonist
    Cloxacepride is an orally active and potent antiallergic agent. Cloxacepride is a CaM (calmodulin) antagonist. Cloxacepride has anti-PCA (passive cutaneous anaphylaxis) activity.
  • HY-19025
    CV-159
    		Antagonist
    CV-159 is a unique dihydropyridine Ca2+ antagonist with an anti-calmodulin (CaM) action, and has antiinflammatory activities.
  • HY-120997
    E6 Berbamine
    		Antagonist
    E6 Berbamine (Berbamine p-nitrobenzoate) is a potent calmodulin (CaM) antagonist. E6 Berbamine inhibits the activity of calmodulin (CaM)-dependent myosin light chain kinase (MLCK), with a Ki of 0.95 μM. E6 Berbamine also shows anti-leukemia activities, with an IC50 of 2.13 μM in K562 cells.
  • HY-125412
    Fasciculic acid B
    		Antagonist
    Fasciculic acid B is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
  • HY-N7733
    Fasciculic acid A
    		Antagonist
    Fasciculic acid A is a steroid that can be isolated from Hypholoma lateritium. Fasciculic acid B has antiinflammatory and calmodulin antagonistic activity.
  • HY-125449
    Fasciculic acid C
    		Antagonist
    Fasciculic acid C is a calmodulin antagonist that can be isolated from mushroom Naematoloma fasciculare.
  • HY-106745
    Elziverine
    		Antagonist
    Elziverine (Ro 22-4839) is a brain circulation improvement agent with vasospasm antispasmodic effects. Elziverine is a calmodulin antagonist. Elziverine inhibits erythrocyte cell membrane rupture, platelet aggregation and lipid peroxidation.