2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. ClpP
  5. ClpP Activator

ClpP Activator

ClpP Activators (6):

Cat. No. Product Name Effect Purity
  • HY-164064
    Anticancer agent 230
    		Activator 99.97%
    Anticancer agent 230 (example 65) is a caseinolytic protease P (ClpP) activator with anticancer activity. Anticancer agent 230 is able to induce the degradation of mitochondrial proteins in SUM159 and MDA-MB-231 triple-negative breast cancer cells in a time-dependent manner.
  • HY-168062
    ZYZ-17
    		Activator
    ZYZ-17 is an activator of human caseinolytic peptidase P ( hClpP), with an EC50 value of 0.24 μM. ZYZ-17 can be used in anticancer research.
  • HY-172199
    THX6
    		Activator
    THX6 is the activator for human mitochondrial protease ClpP with an EC50 of 1.18 μM. THX6 exhibits cytotoxicity in ONC201-resistant cell SU-DIPG-VI with IC50 of 0.13 μM. THX6 inhibits the expression of mitochondrial-related proteins (such as parkin, TFAM, NRF1, SDHA), leads to impaired mitochondrial function. THX6 affects the lipid metabolism in cell membran, and exhibits antitumor potential.
  • HY-173048
    CLPP-2068
    		Activator
    CLPP-2068 is the orally active activator for human caseinolytic protease P (HsClpP) with an EC50 of 50.4 nM. CLPP-2068 exhibits anti-proliferative efficacy in OCI-LY10 cancer cell with an IC50 of 5.2 nM. CLPP-2068 decreases mitochondrial membrane potential, increases mitochondrial ROS levels, and induces mitochondrial dysfunction. CLPP-2068 arrests the cell cycle at G1 phase, and induces apoptosis in cell OCI-LY10. CLPP-2068 exhibits antitumor activity in mouse xenograft models.
  • HY-163319
    NCA029
    		Activator
    NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with an EC50 of 0.15 μM. NCA029 acts on HsClpP to activate an ATF3-dependent integrative stress response, leading to colon cancer cell death.
  • HY-126046
    ACP1b
    		Activator
    ACP1b is an activator for ClpP protease with Kd of 3.2 μM, and exhibits antibacterial activity. ACP1b inhibits N. meningitidis and H. influenzae with MBC of 16 and 8 μg/mL.