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  5. Collagen, Type II, from bovine snout membrane

Collagen, Type II, from bovine snout membrane  (Synonyms: Collagen)

Cat. No.: HY-NP003
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Collagen, Type II, from bovine snout membrane is a type II collagen that can induce osteoarthritis by eliciting a strong and sustained T cell response. Type II collagen can be used to model collagen-induced arthritis in mice.

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Collagen, Type II, from bovine snout membrane Chemical Structure

Collagen, Type II, from bovine snout membrane Chemical Structure

CAS No. : 9007-34-5

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Collagen, Type II, from bovine snout membrane Related Antibodies

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Description

Collagen, Type II, from bovine snout membrane is a type II collagen that can induce osteoarthritis by eliciting a strong and sustained T cell response. Type II collagen can be used to model collagen-induced arthritis in mice[1].

In Vivo

Collagen, Type II, from bovine snout membrane can be used in animal modeling to create arthritis models.

Induction of arthritis[2]
Background
Collagen, Type II, from bovine snout membrane induces arthritis by triggering a strong and sustained T-cell response.
Specific Mmodeling Methods
Mice: DBA/1 • male • 10-12 weeks old
Administration: 200 μg • immunised intradermally in two sites at the base of the tail
Note
(1) All of this collagen is in CFA. To prepare CFA: grind 100 mg of dried inactivated Mycobacterium tuberculosis H37Ra into a fine powder using a mortar and pestle, then suspend it in 30 mL of incomplete Freund's adjuvant.
(2) Fights between male mice reduce the incidence of arthritis. To minimize the risk of fighting, mice older than 6 weeks aren't mixed together in different cages.
(3) Within 2 weeks after the onset of illness (early arthritis) or within 6-8 weeks after the onset of illness (late arthritis), euthanize the arthritis mice, decalcify the joints, embed in paraffin, and conduct histological evaluation.
Modeling Indicators
Molecular changes: Generate strong and sustained T cell responses.
Organizational changes: Inflammatory infiltration and destruction of joints, with a large accumulation of polymorphonuclear cells (PMNs).
Phenotypic observation: Swelling of the claws occurs.
Correlated Product(s): /
Opposite Product(s): Indomethacin (HY-14397)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

[Collagen, Type II, from bovine snout membrane]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
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Collagen, Type II, from bovine snout membrane Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Collagen, Type II, from bovine snout membrane9007-34-5CollagenOthersknee osteoarthritisCTX-IIInhibitorinhibitorinhibit

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