2. Signaling Pathways
  3. Immunology/Inflammation
  4. Cyclophilin

Cyclophilin

Cyclophilins are enzymes that accelerate the rotation of the peptide bond in front of a proline residue. Cyclophilins are involved in a wide variety of cellular processes such as folding, posttranslational modifications and transport of proteins, assembly of essential cellular protein complexes, and cell signaling. Cyclophilins have been identified in a range of organisms, including mammals, plants, insects, fungi, and bacteria.

The prototypic cyclophilin A (CypA) is the most abundant member of the cyclophilin family in human tissue and the major player in the cellular PPIase activity. CypA as a host cell protein interacts with viral proteins and can thus promote or inhibit viral replication and infection of a variety of RNA viruses, most prominently HIV‐1 and HCV.

Cyclophilin Isoform Specific Products:

Cyclophilin Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-157088
    C105SR
    		Inhibitor 99.49%
    C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model.
    C105SR
  • HY-146648
    Cyclophilin inhibitor 3
    		Inhibitor
    Cyclophilin inhibitor 3 (compound 7c) is a potent cyclophilin A (CypA) inhibitor with an potent anti-HCV activity (EC50 of 4.2 μM).
    Cyclophilin inhibitor 3
  • HY-136804
    CypD-IN-29
    		Inhibitor
    CypD-IN-29 (compound 29) is an inhibitor of the Alzheimer's disease target CypD (KD=88.2 nM). CypD is a mitochondrial-specific cyclophilin that can bind to β-amyloid protein in brain mitochondria and promote the formation of mitochondrial permeability transition pore (mPTP).
    CypD-IN-29
  • HY-162536
    Pan-RAS-IN-5
    Pan-RAS-IN-5 (compound 7A) is a molecular glues that can form a ternary complex with the proteins cyclophilin A (CYPA) and RAS (ON). The formation of the ternary complex can block the binding of RAS downstream of RAF and has anti-tumor effects.
    Pan-RAS-IN-5
  • HY-155172
    ZX-J-19j
    ZX-J-19j (Compound ZX-J-19j) is a cyclophilin J inhibitor. ZX-J-19j showes potent antitumor activity.
    ZX-J-19j
  • HY-173011
    RJS308
    		Degrader
    RJS308 is the PROTAC degrader for cyclosporin A (CypA) with a DC50 of 284 nM. RJS308 exhibits antiviral activcity through inhibition of HIV-1 and HCV replication. (Pink: ligand for target protein CypA ligand-2 (HY-173012); Black: linker (HY-W123015); Blue: ligand for E3 ligase VHL (S,R,S)-AHPC-Me (HY-112078))
    RJS308
  • HY-164186
    M9-5 sodium
    M9-5 sodium is an aptamer targeting cyclophilin B. M9-5 binds to the MiaPaCa-2 secretory protein with high affinity and can be used as a blood biomarker for the detection of pancreatic cancer.
    M9-5 sodium
  • HY-173009
    PROTAC CG167
    		Degrader
    PROTAC CG167 is a selective and potent CypA PROTAC degrader. PROTAC CG167 degrades CypA in a dose-dependent manner (Jurkat: DC50: 123 nM). PROTAC CG167 can inhibit HIV-1 and HCV and exhibits antiviral activity. (Pink: CypA Ligand (HY-170997); Black: Linker (HY-W123015); Blue: E3 Ligase Ligand (HY-112078))
    PROTAC CG167
  • HY-173013
    TWH106
    		Inhibitor
    TWH106 is an inhibitor for Cyclophilin (Cyp) that exhibits good affinity to CypA and CypB with KD of 53 nM and 139 nM. TWH106 inhibits the replication of HIV and HCV, exhibiting antiviral activity.
    TWH106
  • HY-P1355
    Cyclosporin A-Derivative 1
    Cyclosporin A-Derivative 1 is a crystalline intermediate derived from the opening of cyclosporin A extracted from patent WO 2013167703 A1. Cyclosporin A is an immunosuppressive agent which can bind to the cyclophilin and inhibit calcineurin.
    Cyclosporin A-Derivative 1
Cyclophilin Isoform Comparison

Cyclophilin A

Cyclophilin B

Cyclophilin C

Cyclophilin D

Cyclophilin G

Cyclophilin E

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Cyclophilin Degraders & Inhibitors
Product NameCyclophilin ACyclophilin BCyclophilin CCyclophilin DCyclophilin GCyclophilin EPurity    
Cyclosporin A   
Cyclophilin D
  99.94%
TMN355
Cyclophilin A
     99.69%
HL001
Cyclophilin A
     
Rencofilstat
Cyclophilin A, IC50: 2.5 nM
Cyclophilin B, IC50: 3.1 nM
 
Cyclophilin D, IC50: 2.8 nM
Cyclophilin G, IC50: 7.3 nM
 
Cyclophilin inhibitor 1
Cyclophilin A
     99.55%
CypD-IN-4
Cyclophilin A, IC50: 3.4 μM
Cyclophilin B, IC50: 1.1 μM
 
Cyclophilin D, IC50: 0.057 μM
 
Cyclophilin E, IC50: 0.8 μM
CypD-IN-3
Cyclophilin A, IC50: 1.1 μM
Cyclophilin B, IC50: 0.21 μM
 
Cyclophilin D, IC50: 0.01 μM
 
Cyclophilin E, IC50: 0.31 μM
CypE-IN-1
Cyclophilin A, IC50: 3 μM
Cyclophilin A, Ki: 1.8 μM
Cyclophilin B, IC50: 4 μM
Cyclophilin B, Ki: 5.6 μM
Cyclophilin C, IC50: 17 μM
Cyclophilin D, IC50: 0.6 μM
Cyclophilin D, Ki: 0.52 μM
Cyclophilin G, IC50: 40 μM
Cyclophilin E, IC50: 0.013 μM
Cyclophilin E, Ki: 0.072 μM
C105SR   
Cyclophilin D, IC50: 5 nM
  99.49%
Cyclophilin inhibitor 3
Cyclophilin A
     
PROTAC CG167
Cyclophilin A, DC50: 123 nM
     
TWH106
Cyclophilin A, Kd: 53 nM
Cyclophilin B, Kd: 139 nM