2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Dihydrofolate reductase (DHFR)

Dihydrofolate reductase (DHFR)

Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate using NADPH, and it is involved in the synthesis of nucleotide, in both prokaryotic and eukaryotic cells. DHFR inhibitors are commonly used for fighting malaria and other protozoal infections, as well as for treating fungal, bacterial, and mycobacterial infections.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125647
    10-Deazaaminopterin
    		Inhibitor
    10-Deazaaminopterin is a potent inhibitor of dihydrofolate reductase. 10-Deazaaminopterin can used in study advanced cancer.
    10-Deazaaminopterin
  • HY-168069
    DHFR-IN-20
    		Inhibitor
    DHFR-IN-20 (Compound LA1) is a Plasmodium falciparum dihydrofolate reductase (DHFR) inhibitor, with Kis of 0.16, 0.30, 6.6 nM for PfDHFR-WT, PfDHFR-QM, HsDHFR. DHFR-IN-20 has antimalarial activities (IC50: 1.4 nM and 1.6 μM for P. falciparum carrying the wild-type (TM4/8.2) and the quadruple mutant (V1/S) PfDHFR enzyme.
    DHFR-IN-20
  • HY-119613
    Clociguanil
    		Inhibitor
    Clociguanil (BRL 50216), a DHFR inhibitor (IC50: 55.6 nM), is an antimalarial agent. Clociguanil has sympathomimetic and antiarrhythmic action.
    Clociguanil
  • HY-161292
    DHFR-IN-16
    		Inhibitor
    DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) (IC50=0.199 μM) and can be used in anti-infectious research.
    DHFR-IN-16
  • HY-118251
    PD130883
    		Inhibitor
    PD130883 is an antifolate DHFR inhibitor that directly inhibits thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site, reducing the net conversion of tetrahydrofolate cofactor to dihydrofolate.
    PD130883
  • HY-169211
    DHFR-IN-21
    		Inhibitor
    DHFR-IN-21 (compund 5p) is a dihydrofolate reductase (DHFR) inhibitor.
    DHFR-IN-21
  • HY-149459A
    Phototrexate
    		Inhibitor
    Phototrexate is a photoswitchable inhibitor of the human dihydrofolate reductase (DHFR). Phototrexate has antifolate and antiproliferative properties, which can be used for the research of cancer.
    Phototrexate
  • HY-156414
    DHFR-IN-11
    		Inhibitor
    DHFR-IN-11 (compound 6b) is inhibitor of DHFR, and has inhibitory potency versus M. tuberculosis DHFR enzyme with IC50 values 5.70 μM.
    DHFR-IN-11
  • HY-161063
    DHFR-IN-14
    		Inhibitor
    DHFR-IN-14 (compound 32) is a pyrimethamine (Pyr)-type, dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity.
    DHFR-IN-14
  • HY-163725
    DHFR-IN-18
    		Inhibitor
    DHFR-IN-18 (compound 19D) is a DHFR inhibitor. DHFR-IN-18 can be used in anti-leukemia research.
    DHFR-IN-18
  • HY-149699
    DHFR-IN-12
    		Inhibitor
    DHFR-IN-12 (Compound 5c) is a DHFR inhibitor which has good antibacterial activity.
    DHFR-IN-12
  • HY-153007A
    DHFR-IN-5 hydrochloride
    		Inhibitor
    DHFR-IN-5 hydrochloride is a potent and orally active dihydrofolate reductase (DHFR) inhibitor with a Ki value of 0.54 nM for quadruple mutant Plasmodium falciparum DHFR. DHFR-IN-5 hydrochloride shows anti-malaria activity.
    DHFR-IN-5 hydrochloride
  • HY-N3764
    Diosbulbin C
    		Activator
    Diosbulbin C is a diterpene lactone component, which can be extracted from traditional Chinese medicine Dioscorea bulbifera L.. Diosbulbin C possesses high anticancer activity in non-small cell lung cancer (NSCLC). Diosbulbin C could induce cell cycle arrest at G0/G1 phase in NSCLC. Diosbulbin C also inhibits the proliferation of NSCLC cells, possibly by downregulating the expression/activation of AKT, DHFR, and TYMS.
    Diosbulbin C
  • HY-162656
    DHFR-IN-19
    		Inhibitor
    DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with Ki of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC50 of 14.5 μM.
    DHFR-IN-19
  • HY-115836
    DDPO
    		Inhibitor
    DDPO is an inhibitor for dihydrofolate reductase (DHFR) with an IC50 of 0.035 µM. DDPO inhibits the cell growth of cancer cell L1210 and WI-L2with IC50 of 5 and 0.28 µM.
    DDPO
Cat. No. Product Name / Synonyms Application Reactivity