2. Signaling Pathways
  3. Disulfidptosis
  4. Disulfidptosis Inhibitor

Disulfidptosis Inhibitor

Disulfidptosis Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-15763
    Erastin
    		Inhibitor 99.76%
    Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation.
  • HY-15917
    DL-dithiothreitol
    		Inhibitor 99.43%
    DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.
  • HY-15917S2
    DL-dithiothreitol-d6
    		Inhibitor ≥99.0%
    DL-dithiothreitol-d6 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond.
  • HY-15917S
    DL-dithiothreitol-d10
    		Inhibitor
    DL-dithiothreitol-d10 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.
  • HY-15917S1
    DL-dithiothreitol-d10-1
    		Inhibitor
    DL-dithiothreitol-d10-1 is the deuterated form of DL-dithiothreitol. DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. DL-dithiothreitol is oxidized to form a stable six-membered ring with an internal disulfide bond.