Emopamil Binding Protein

Emopamil Binding Protein (EBP) is a membrane-bound cholesterol biosynthetic enzyme involved in the key steps of cholesterol synthesis and a target for neuroprotective agents. It belongs to the extended EBP superfamily. Emopamil Binding Protein is mainly localized in the endoplasmic reticulum membrane and widely expressed in various tissues, especially the liver. EBP can bind to chemotherapeutic drugs, reducing their effectiveness and leading to tumor resistance.

References:

[1]. Emopamil. Pharmacology, Toxicology and Pharmaceutical Science. Sciencedirect.

[2]. Silve S, et al. Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast. J Biol Chem. 1996 Sep 13;271(37):22434-40. [Content Brief]

[3]. Reardon D A, et al. DSP-0390, an oral emopamil binding protein (EBP) inhibitor, in patients with recurrent high-grade glioma: A first-in-human, phase 1 study[J]. 2022.

Emopamil Binding Protein Inhibitor (1)

Emopamil Binding Protein Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-162351

EBP-IN-1	Inhibitor	99.67%
EBP-IN-1 (compound 11) is an inhibitor of emopamil-binding protein (EBP), a sterol isomerase in the cholesterol biosynthetic pathway. EBP-IN-1 has a long half-life in rodents and has good metabolic turnover and brain penetration properties. EBP-IN-1 enhances oligodendrocyte formation in human cortical organoids.

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