2. Signaling Pathways
  3. Anti-infection
  4. Flavivirus

Flavivirus

 
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16134
    Celgosivir
    Celgosivir (MBI 3253; MDL 28574; MX3253) is an α-glucosidase I inhibitor; inhibits bovine viral diarrhoea virus (BVDV) with an IC50 of 1.27 μM in in vitro assay.
    Celgosivir
  • HY-108908
    (Rac)-Modipafant
    		98.15%
    (Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection.
    (Rac)-Modipafant
  • HY-132174
    CHIKV-IN-2
    		99.21%
    CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC90=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools.
    CHIKV-IN-2
  • HY-N3942
    Glabranine
    		Inhibitor ≥98.0%
    Glabranine, an flavonoid, is isolated from Tephrosia s.p, exerts a inhibitory effect in vitro on the dengue virus. Glabranine forms interaction with the soluble ectodomain of DENV type 2 (DENV2) E protein.
    Glabranine
  • HY-N12710
    Crenatoside
    		Inhibitor ≥98.0%
    Crenatoside is a phenylethanol glycoside compound that can be isolated from the ethyl acetate of the tree extract of T. stans var. stans with EC50 value of 34.78 μM. Crenatoside has anti-Zika virus activity.
    Crenatoside
  • HY-131976
    BVDV-IN-1
    		Inhibitor 98.01%
    BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC).
    BVDV-IN-1
  • HY-144612
    NS2B/NS3-IN-2
    NS2B/NS3-IN-2 is a potent dengue virus (DENV) NS2B/NS3 covalent inhibitor with an IC50 of 6.0 nM and Ki of 0.66 µM. NS2B/NS3-IN-2 shows no cytotoxicity and markedly increases the cell survival rate.
    NS2B/NS3-IN-2
  • HY-W010668
    Quinine sulfate hydrate
    		99.97%
    Quinine sulfate hydrate (2:1:4) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate hydrate (2:1:4) is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100?mV with an IC50 of 169 μM.
    Quinine sulfate hydrate
  • HY-150234
    LabMol-319
    		Inhibitor
    LabMol-319 is a potent zika virus (ZIKV) NS5 RdRp inhibitor with an IC50 of 1.6 μM. LabMol-319 is an antiviral agent.
    LabMol-319
  • HY-112254
    ZINC03129319
    		98.50%
    ZINC03129319 is a dengue virus (DENV) NS2B-NS3 protease inhibitor extracted from patent US20150141521A1, has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
    ZINC03129319
  • HY-B0190B
    Nafamostat hydrochloride
    Nafamostat hydrochloride, an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat hydrochloride has anticancer and antivirus effect. Nafamostat hydrochloride induces apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat hydrochloride can be used in the development of the pathological thickening of the arterial wall.
    Nafamostat hydrochloride
  • HY-124618
    FGI-106
    FGI-106 is a potent and broad-spectrum inhibitor with inhibitory activity against multiple viruses. FGI-106 is active against Ebola, Rift Valley and Dengue Fever viruses with EC50s of 100 nM, 800 nM and 400-900 nM, respectively. FGI-106 also inhibits non-hemorrhagic fever viruses HCV and HIV-1 with EC50s of 200 nM and 150 nM, respectively.
    FGI-106
  • HY-D0143A
    Quinine dihydrochloride
    Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
    Quinine dihydrochloride
  • HY-B0433B
    Quinine hemisulfate
    Quinine hemisulfate is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine hemisulfate is a potassium channel inhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with an IC50 of 169 μM.
    Quinine hemisulfate
  • HY-150600
    NS2B/NS3-IN-7
    		Inhibitor
    NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells.
    NS2B/NS3-IN-7
  • HY-B0421S2
    Mycophenolic acid-13C17
    		Inhibitor
    Mycophenolic acid-13C17 (Mycophenolate-13C17) is the 13C labeled Mycophenolic acid (HY-B0421). Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
    Mycophenolic acid-<sup>13</sup>C<sub>17</sub>
  • HY-152083
    DENV-IN-9
    DENV-IN-9 (Compound 5f) is a DENV2 inhibitor with an EC50 of 0.88 μM.
    DENV-IN-9
  • HY-B1030R
    Lanatoside C (Standard)
    Lanatoside C (Standard) is the analytical standard of Lanatoside C. This product is intended for research and analytical applications. Lanatoside C is a cardiac glycoside, can be used in the treatment of congestive heart failure and cardiac arrhythmia.Lanatoside C has an IC50 of 0.19 μM for dengue virus infection in HuH-7 cells. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya, Sindbis virus and the human enterovirus 71.
    Lanatoside C (Standard)
  • HY-146193
    Zika virus-IN-3
    Zika virus-IN-3 (Compd 7) is a Zika virus inhibitor, with an EC50 of 3.4 μM .
    Zika virus-IN-3
  • HY-146417
    Antiviral agent 19
    Antiviral agent 19 (Compound 3) is a selective inhibitor against Zika virus infection with an EC50 of 1.3 µM. Antiviral agent 19 has low cytotoxicity.
    Antiviral agent 19
Cat. No. Product Name / Synonyms Application Reactivity