2. Signaling Pathways
  3. GPCR/G Protein
  4. Formyl Peptide Receptor (FPR)
  5. Formyl Peptide Receptor (FPR) Agonist

Formyl Peptide Receptor (FPR) Agonist

Formyl Peptide Receptor (FPR) Agonists (7):

Cat. No. Product Name Effect Purity
  • HY-P10724
    fMIFL
    		Agonist
    fMIFL is an FPR1 agonist. fMIFL can activate several signaling pathways responsible for various neutrophil functions, such as adhesion, chemotaxis, secretion of granule exocytosis, and the production of superoxide anions. fMIFL can be used in research on bacterial infections and tissue damage.
  • HY-159583
    FPR2 agonist 4
    		Agonist
    FPR2 agonist 4 (compound 20) is a selective agonist of FPR2 with an EC50 of 0.2 nM.
  • HY-144604
    FPR2 agonist 2
    		Agonist 99.59%
    FPR2 agonist 2 is a potent and permeates the blood?brain barrier FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity.
  • HY-103472
    FPR-A14
    		Agonist 99.90%
    FPR-A14 is a potent formyl peptide receptor (FPR) agonist. FPR-A14 is a potent activator of neutrophil Ca2+ mobilization and chemotaxis with EC50s of 630 nM and 42 nM, respectively. FPR-A14 induces cell differentiation.
  • HY-P1117
    MMK1
    		Agonist 99.22%
    MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity.
  • HY-155335
    FPR2 agonist 3
    		Agonist
    FPR2 agonist 3 (compound CMC23) can limit the lactate dehydrogenase release in LPS (HY-D1056) -stimulated cultures and decrease the levels of pro-inflammatory IL-1β and IL-6. FPR2 agonist 3 decrease the level of phosphor-STAT3 via the STAT3/SOCS3 signaling pathway.
  • HY-P1117A
    MMK1 TFA
    		Agonist
    MMK1 TFA is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 TFA is a potent chemotactic and calcium-mobilizing agonist. MMK1 TFA potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 TFA exerts anxiolytic-like activity.