2. Signaling Pathways
  3. GPCR/G Protein
  4. GCGR
  5. GCGR Inhibitor

GCGR Inhibitor

GCGR Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-10930
    UNC0321
    		Inhibitor 99.91%
    UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications.
  • HY-P99357
    Crotedumab
    		Inhibitor
    Crotedumab (REGN1193) is a fully human IgG4 monoclonal antibody that binds and inhibits glucagon receptor (GCGR), with a KD of 0.1 nM. Crotedumab can be used for the research of diabetes.
  • HY-P0150
    Glucagon (19-29), human
    		Inhibitor 99.11%
    Glucagon (19-29), human is a potent and efficient inhibitor of insulin secretion.
  • HY-50675
    GRA Ex-25
    		Inhibitor 98.59%
    GRA Ex-25 is an inhibitor of glucagon receptor, with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively.
  • HY-P990013
    Gulgafafusp alfa
    		Inhibitor
    Gulgafafusp alfa is a human IgG2κ antibody targeting the glucagon-like peptide 1 receptor GLP1R.
  • HY-159696
    ISIS 449884
    		Inhibitor
    ISIS 449884 is a 2'-O-methoxyethyl antisense oligonucleotide that targets GCGR. ISIS 449884 has an ability to reduce hepatic glucose output and lower the blood glucose level. ISIS 449884 can be used for the study of type 2 diabetes mellitus (T2DM).
  • HY-159696A
    ISIS 449884 sodium
    		Inhibitor
    ISIS 449884 sodium is a 2'-O-methoxyethyl antisense oligonucleotide that targets GCGR. ISIS 449884 sodium has an ability to reduce hepatic glucose output and lower the blood glucose level. ISIS 449884 sodium can be used for the study of type 2 diabetes mellitus (T2DM).