2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. GGTase
  5. GGTase Inhibitor

GGTase Inhibitor

GGTase Isoform Comparison

GGTase Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-16229A
    GGTI-2154 hydrochloride
    		Inhibitor 98.93%
    GGTI-2154 hydrochloride is a potent and selective inhibitor geranylgeranyltransferase I (GGTase I), with an IC50 of 21 nM. GGTI-2154 hydrochloride shows more than 200-fold selectivity for GGTase I over FTase (IC50=5600 nM). GGTI-2154 hydrochloride can be used for the research of cancer.
  • HY-161573
    BAY-593
    		Inhibitor 99.94%
    BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity.
  • HY-161573A
    (7S)-BAY-593
    		Inhibitor 99.61%
    (7S)-BAY-593 is the S-enantiomer of BAY-593 (HY-161573). BAY-593 is an orally active GGTase-I inhibitor. BAY-593 can block YAP1/TAZ signaling in animals and has antitumor activity.
  • HY-161573B
    BAY-593 hydrochloride
    		Inhibitor
    BAY-593 (hydrochloride) is an orally active GGTase-I inhibitor. BAY-593 (hydrochloride) can block YAP1/TAZ signaling in animals and has antitumor activity.