2. Signaling Pathways
  3. Anti-infection
  4. HPV

HPV

Human papillomavirus

Human papillomavirus (HPV) is the most common sexually transmitted infection (STI) that commonly causes skin or mucous membrane growths (warts). HPV is a virus with double-stranded circular DNA from the papillomavirus family. All HPVs have icosahedral capsids. HPV displays tropism toward the epithelial basal layer, which houses adult epithelial stem cells responsible for replenishing the epithelium with daughter cells. There are more than 100 varieties of human papillomavirus (HPV). Some types of HPV infection cause warts, and some (HPV 16 and 18) can cause different types of cancer, including cancers of the anus, penis, vagina, vulva and back of the throat (oropharyngeal). Worldwide, the risk of being infected at least once in a lifetime among both men and women is 50%. Vaccines can help protect against the strains of HPV most likely to cause genital warts or cervical cancer.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P10428
    E6AP-mimicking peptide
    		Inhibitor
    E6AP-mimicking peptide (compound 13) is a high-affinity, selective, irreversible and potent peptide-based covalent HPV16 E6 inhibitor targeting the 16E6 oncoprotein using a cysteine-reactive acrylamide warhead. E6AP-mimicking peptide has a Ki of 17 nM. E6AP-mimicking peptide targets all residues appearing in the binding pocket of E6 to disrupt the binding interface of 16E6 and E6AP. E6AP-mimicking peptide selectively binds and crosslinks to MBP-16E6 in PBS or a protein mixture.
    E6AP-mimicking peptide
  • HY-119151
    GS-9191
    		Inducer
    GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection.
    GS-9191
  • HY-P2299
    Protein E7(43-62)
    Protein E7(43-62) is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein).
    Protein E7(43-62)
  • HY-P1778
    HPV16 E7 (86-93)
    HPV16 E7 (86-93) is a human leukocyte antigen (HLA)-A2.1 restricted HPV16 E7-derived peptide. HPV16 E7 (86-93) is immunogenic in cervical carcinomas.
    HPV16 E7 (86-93)
  • HY-P5694
    Human α-defensin 5
    		Inhibitor
    Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16). Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity.
    Human α-defensin 5
  • HY-P1881
    HPV16-E711-20 epitope
    HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro. HPV16 CTL epitopes may be good candidates for the development of an effective peptide-based antitumor vaccine.
    HPV16-E711-20 epitope
  • HY-P2299A
    Protein E7(43-62) TFA
    Protein E7(43-62) TFA is an E7-derived peptide with anti-tumor effects (short peptide spanning the 43th to 62th amino acid residues in the E7 protein).
    Protein E7(43-62) TFA
  • HY-10221R
    Vorinostat (Standard)
    		Inhibitor
    Vorinostat (Standard) is the analytical standard of Vorinostat. This product is intended for research and analytical applications. Vorinostat (SAHA) is a potent and orally active pan-inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC6 and HDAC7 (Class II) and HDAC11 (Class IV), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively. Vorinostat induces cell apoptosis. Vorinostat is also an effective inhibitor of human papillomaviruse (HPV)-18 DNA amplification.
    Vorinostat (Standard)
  • HY-129253
    GSK984
    		Control
    GSK984 is an inactive control probe for GSK983 (HY-119098), a dihydroorotate dehydrogenase (DHODH) inhibitor with antiviral activity.
    GSK984
  • HY-107801R
    Inosine pranobex (Standard)
    		Inhibitor
    Inosine pranobex (Standard) is the analytical standard of Inosine pranobex. This product is intended for research and analytical applications. Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .
    Inosine pranobex (Standard)
Cat. No. Product Name / Synonyms Species Source