2. Signaling Pathways
  3. GPCR/G Protein
  4. Hydroxycarboxylic Acid Receptor (HCAR)
  5. Hydroxycarboxylic Acid Receptor (HCAR) Inhibitor

Hydroxycarboxylic Acid Receptor (HCAR) Inhibitor

Hydroxycarboxylic Acid Receptor (HCAR) Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-135982
    GPR81 agonist 1
    		Inhibitor 99.73%
    GPR81 agonist 1 is a potent and highly selective GPR81 agonist, with EC50s of 58 nM and 50 nM for human and mouse GPR81, respectively. GPR81 agonist 1 inhibits lipolysis in differentiated 3T3-L1 adipocytes. GPR81 agonist 1 suppresses lipolysis in mice without cutaneous flushing. GPR81 agonist 1 displays remarkable selectivity for GPR81 over GPR109a.
  • HY-W016868
    3-Chloro-5-hydroxybenzoic acid
    		Inhibitor 99.54%
    3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity.
  • HY-148563
    GPR81 agonist 2
    		Inhibitor
    GPR81 agonist 2 (compound 1) is a potent GPR81 agonist with EC50 values of 0.023, 0.123 µM for hGPR81, hGPR109A, respectively.