2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. iGluR
  5. iGluR Activator

iGluR Activator

iGluR Isoform Comparison

iGluR Activators (17):

Cat. No. Product Name Effect Purity
  • HY-N2370
    24-Hydroxycholesterol
    		Activator 99.90%
    24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
  • HY-115864
    Osavampator
    		Activator 99.89%
    Osavampator (TAK-653) is a AMPA receptor positive allosteric modulator. Osavampator selectively binds to AMPA-R in a glutamate-dependent manner and induces Ca2+ influx in hGluA1i CHO cells (EC50 = 3.3 μM). Osavampator improves learning and memory in many models. Osavampator is can be used for the research of depressive disorders.
  • HY-18699
    CIQ
    		Activator 99.75%
    CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.
  • HY-12597
    Quisqualic acid
    		Activator ≥98.0%
    Quisqualic acid (L-Quisqualic acid), a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica.
  • HY-12509
    PEPA
    		Activator 99.87%
    PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
  • HY-17555
    Meclofenoxate hydrochloride
    		Activator 98.80%
    Meclofenoxate (Centrophenoxine) hydrochloride is an ester synthesized from DMAE and pCPA, capable of crossing the blood-brain barrier, and can stimulate memory and enhance cognition.
  • HY-17553
    Coluracetam
    		Activator 99.87%
    Coluracetam (MKC-231) is an orally taken choline uptake enhancer. Coluracetam can improve the reduced acetylcholine levels in the hippocampus of rats and mice, enhancing learning difficulties, memory deficits, and cognitive impairments. Coluracetam induces a lower degree of hepatic venous hyperglycemia.
  • HY-10934
    Mibampator
    		Activator 99.86%
    Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors.
  • HY-10935
    LY450108
    		Activator 99.51%
    LY450108 is a potent AMPA receptor potentiator. LY450108 has the potential for depression and Parkinson's disease research.
  • HY-103235
    NPEC-caged-(S)-AMPA
    		Activator
    NPEC- caged-(S)-AMPA, a caged neurotransmitter analog, is a NPEC photoprotecting group caged the (S)-AMPA (HY-100815A) to make caged ligands specific for glutamate receptor sub-types. NPEC- caged-(S)-AMPA selectively activates AMPA receptor.
  • HY-17555A
    Meclofenoxate
    		Activator
    Meclofenoxate (Centrophenoxine) is an ester synthesized from DMAE and pCPA, which has the activity of stimulating memory and improving cognition.
  • HY-P3340
    Leptin (116-130)
    		Activator
    Leptin (116-130) is a bioactive leptin fragment. Leptin (116-130) promotes AMPA receptor trafficking to synapses and facilitate activity-dependent hippocampal synaptic plasticity. Leptin (116-130) prevents hippocampal synaptic disruption and neuronal cell death in models of amyloid toxicity. Leptin (116-130) has the potential for the research of Alzheimer's disease (AD).
  • HY-125931
    Unifiram
    		Activator 99.78%
    Unifiram (DM232) is acts as a potent cognition enhancer through the activation of the AMPA-mediated neurotransmission system. Unifiram (DM232) has the potential for amnesia prevention and neurodegenerative disorder research.
  • HY-149975
    AMPA receptor modulator-4
    		Activator
    AMPA receptor modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), is an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). AMPA receptor modulator-4 can cross the blood-brain barrier. AMPA receptor modulator-4 increases the cognition performance and improves working memory performance in mice.
  • HY-17555R
    Meclofenoxate hydrochloride (Standard)
    		Activator
    Meclofenoxate (hydrochloride) (Standard) is the analytical standard of Meclofenoxate (hydrochloride). This product is intended for research and analytical applications. Meclofenoxate hydrochloride is an ester synthesized from DMAE and pCPA, which has the activity of stimulating memory and improving cognition.
  • HY-17553R
    Coluracetam (Standard)
    		Activator
    Coluracetam (Standard) is the analytical standard of Coluracetam. This product is intended for research and analytical applications. Coluracetam (MKC-231) is a new choline absorption enhancer.
  • HY-123904
    UoS12258
    		Activator
    UoS12258 is a selective positive allosteric modulator of AMPA receptor. UoS12258 enhances AMPA receptor‐mediated synaptic transmission. UoS12258 improves performance in cognition rat models, including Scopolamine (HY-N0296)‐impaired rats and water maze learning and retention in aged rats.