2. Signaling Pathways
  3. GPCR/G Protein
  4. ICMT

ICMT

Isoprenylcysteine carboxyl methyltransferase

ICMT (Isoprenylcysteine carboxyl methyltransferase) is an enzyme involved in complex post-translational modification processes and plays a key role in the post-translational regulation of prenylated proteins. ICMT primarily catalyzes the methylation of post-translationally isoprene-methylated C-terminal cysteine residues and targets these proteins to the cell membrane. This modification provides the substrate protein with a hydrophobic uncharged C terminus, thereby enhancing interaction with biological membranes and/or altering the ability to interact with protein partners. ICMT-catalyzed protein prenylation may play a role in cancer. Examples include ICMT-modified RHO GTPases or Ras family members. When the ICMT gene is knocked out, it can inhibit KRAS-induced embryonic fibroblast transformation and inhibit RAS-driven tumorigenesis; or ICMT inhibition can hinder RHO GTPase-related cancer cell invasiveness and metastasis[1][2].

ICMT Related Products (66):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16160
    Cysmethynil
    		99.87%
    Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research.
    Cysmethynil
  • HY-156500
    ICMT-IN-1
    		Inhibitor
    ICMT-IN-1 (compound 75) is an inhibitor of ICMT (IC50=0.0013 μM). ICMT-IN-1 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras.
    ICMT-IN-1
  • HY-155433
    ICMT-IN-30
    		Inhibitor
    ICMT-IN-30 (compound 67) is an inhibitor of ICMT (IC50=0.27 μM).
    ICMT-IN-30
  • HY-157092A
    (S)-ICMT-IN-3
    		Inhibitor
    (S)-ICMT-IN-3 (compound ent 1-27) is an inhibitor of ICMT (IC50=0.23 μM).
    (S)-ICMT-IN-3
  • HY-155431
    ICMT-IN-28
    		Inhibitor
    ICMT-IN-28 (compound 65) is an inhibitor of ICMT (IC50=0.008 μM).
    ICMT-IN-28
  • HY-157120
    ICMT-IN-52
    		Inhibitor
    ICMT-IN-52 (compound 44) is an inhibitor of ICMT (IC50=0.052 μM).
    ICMT-IN-52
  • HY-155419
    ICMT-IN-5
    		Inhibitor
    ICMT-IN-5 (compound 46) is an inhibitor of ICMT (IC50=0.3 μM).
    ICMT-IN-5
  • HY-157103
    ICMT-IN-34
    		Inhibitor
    ICMT-IN-34 (compound 39) is an inhibitor of ICMT (IC50=0.17 μM).
    ICMT-IN-34
  • HY-157119
    ICMT-IN-51
    		Inhibitor
    ICMT-IN-51 (compound 43) is an inhibitor of ICMT (IC50=0.55 μM).
    ICMT-IN-51
  • HY-149705
    ICMT-IN-7
    		Inhibitor
    ICMT-IN-7 (compound 74) is an inhibitor of ICMT (IC50=0.015 μM). ICMT-IN-7 dose-dependently induces ICMT accumulation in the cytoplasm of HCT-116 cells and inhibits the proliferation of multiple cancer cell lines expressing K-Ras and N-Ras.
    ICMT-IN-7
  • HY-157095
    ICMT-IN-6
    		Inhibitor
    ICMT-IN-6 (compound 29) is an inhibitor of ICMT (IC50=0.09 μM).
    ICMT-IN-6
  • HY-157118
    ICMT-IN-50
    		Inhibitor
    ICMT-IN-50 (compound 3) is an inhibitor of ICMT (IC50=0.31 μM).
    ICMT-IN-50
  • HY-155429
    ICMT-IN-24
    		Inhibitor
    ICMT-IN-24 (compound 63) is an inhibitor of ICMT (IC50=0.19 μM).
    ICMT-IN-24
  • HY-155424
    ICMT-IN-15
    		Inhibitor
    ICMT-IN-15 (compound 51) is an inhibitor of ICMT (IC50=0.032 μM).
    ICMT-IN-15
  • HY-155422
    ICMT-IN-13
    		Inhibitor
    ICMT-IN-13 (compound 49) is an inhibitor of ICMT (IC50=0.47 μM).
    ICMT-IN-13
  • HY-157114
    ICMT-IN-46
    		Inhibitor
    ICMT-IN-46 (compound 25) is an inhibitor of ICMT (IC50=0.556 μM).
    ICMT-IN-46
  • HY-157105
    ICMT-IN-37
    		Inhibitor
    ICMT-IN-37 (compound 41) is an inhibitor of ICMT (IC50=0.308 μM).
    ICMT-IN-37
  • HY-155430
    ICMT-IN-27
    		Inhibitor
    ICMT-IN-27 (compound 64) is an inhibitor of ICMT (IC50=0.1 μM).
    ICMT-IN-27
  • HY-155427
    ICMT-IN-20
    		Inhibitor
    ICMT-IN-20 (compound 54) is an inhibitor of ICMT (IC50=0.682 μM).
    ICMT-IN-20
  • HY-157112
    ICMT-IN-44
    		Inhibitor
    ICMT-IN-44 (compound 23) is an inhibitor of ICMT (IC50=0.167 μM).
    ICMT-IN-44