2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. LOX-1
  5. LOX-1 Inhibitor

LOX-1 Inhibitor

LOX-1 Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-149922
    DKI5
    		Inhibitor 98.12%
    DKI5, also known as (E)-N’-benzylidenehydrazinecarbothiohydrazide, is a LOX-1 inhibitor with an IC50 value of 22.5 μM.
  • HY-149269
    COX-2-IN-30
    		Inhibitor
    COX-2-IN-30 is a benzenesulfonamide derivative, as well as an orally active and dual inhibitor of COX (IC50=49 nM for COX-2, 10.4 μM for COX-1) and 5-LOX (IC50=2.4 μM). COX-2-IN-30 also inhibits transmembrane hCA IX and hCA XII isoform with nanomolar calss Ki values. COX-2-IN-30 exhibits analgesic, anti-inflammatory, and ulcerogenic activities, and does not show acute gastric effect.