2. Neuronal Signaling Immunology/Inflammation Metabolic Enzyme/Protease
  3. Cholinesterase (ChE) Monoamine Oxidase Beta-secretase COX LOX-1
  4. AChE-IN-82

AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2.

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AChE-IN-82 Chemical Structure

AChE-IN-82 Chemical Structure

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AChE-IN-82 Related Antibodies

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AChE BChE

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MAO-A MAO-B

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BACE1 BACE2

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COX COX-1 COX-2 COX-3

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Description

AChE-IN-82 (compound 49) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-82 inhibits eeAChE, eqBChE, hMAO-A, hMAO-B, and BACE-1 with IC50s of 0.072, 9.81, 14.52, 0.024, 2.42 μM, respectively. AChE-IN-82 inhibits COX-1, COX-2 and 5-LOX with IC50s of 60.41, 0.187, 0.18 μM, respectively. AChE-IN-82 shows an excellent neuroprotective effect by significantly reducing oxidative stress induced by H2 O2[1].

IC50 & Target[1]

EeAChE

0.072 μM (IC50)

eqBCHE

9.81 μM (IC50)

hMAO-A

14.52 μM (IC50)

hMAO-B

0.024 μM (IC50)

BACE1

2.42 μM (IC50)

COX-1

60.41 μM (IC50)

COX-2

0.187 μM (IC50)

Molecular Weight

470.52

Formula

C21H18N4O5S2
SMILES

COC1=C(O)C=CC(/C=C/C(NC2=CC(N=C(NCN3C(SCC3=O)=O)S4)=C4C=C2)=O)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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AChE-IN-82 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-82Cholinesterase (ChE)Monoamine OxidaseBeta-secretaseCOXLOX-1MAOBACEβ-Secretase CyclooxygenaseLectin-like oxidized low-density lipoprotein receptor-1Alzheimer’s diseaseNeuroinflammationsoxidative stressSH-SY5Y ceInhibitorinhibitorinhibit

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