2. Signaling Pathways
  3. Immunology/Inflammation
  4. Macrophage migration inhibitory factor (MIF)

Macrophage migration inhibitory factor (MIF)

Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine encoded within a functionally polymorphic genetic locus. MIF is a highly conserved 12.5 kDa secretory protein that is involved in numerous biological processes. The expression and secretion profile of MIF suggests that MIF to be ubiquitously and constitutively expressed in almost all mammalian cells and is vital for numerous physiological processes. MIF is a pleiotropic inflammatory cytokine important in the upstream regulation of both innate and adaptive immunological responses and has been implicated in the pathogenesis of autoimmune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).

Macrophage migration inhibitory factor (MIF) Related Products (23):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146318
    MIF-IN-5
    		Inhibitor
    MIF-IN-5 (compound 1d) is a potent and reversible macrophage migration inhibitory factor (MIF) competitive inhibitor with an IC50 of 4.8 μM and a Ki value of 3.3 μM, respectively.
    MIF-IN-5
  • HY-144195
    MIF-IN-3
    		Inhibitor
    MIF-IN-3 is a migration inhibitory factor (MIF) inhibitor extracted from patent WO2021258272A1 compound 31. MIF-IN-3 can be used for the research of immune inflammation-related diseases.
    MIF-IN-3
  • HY-17009R
    Iguratimod (Standard)
    		Inhibitor
    Iguratimod (Standard) is the analytical standard of Iguratimod. This product is intended for research and analytical applications. Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC50 of 6.81 μM.
    Iguratimod (Standard)