Macrophage migration inhibitory factor (MIF) Inhibitor

Macrophage migration inhibitory factor (MIF) Inhibitors (22):

Cat. No.	Product Name	Effect	Purity

HY-16692

ISO-1	Inhibitor	99.94%
ISO-1 is a macrophage migration inhibitory factor (MIF) antagonist with an IC₅₀ of 7 μM.

HY-110063

4-IPP	Inhibitor	99.46%
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF).

HY-17009

Iguratimod	Inhibitor	99.93%
Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2, with an IC₅₀ of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor (MIF) with an IC₅₀ of 6.81 μM.

HY-147390

MIF098	Inhibitor	99.88%
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist. MIF098 inhibits proliferation, migration and fibrosis of pulmonary smooth muscle cells. MIF098 can be used for immunoinflammation-related disease research.

HY-167880

BMY-25551	Inhibitor
BMY-25551 is a Mitomycin A (HY-130332) analogue that is 8 to 20 times more potent than Mitomycin C (HY-13316) in cytotoxicity to murine and human tumor cell lines. BMY-25551 can be utilized in cancer and hematologic depression research.

HY-159086

RGB097	Inhibitor
RGB097 is a potent D-dopachrome tautomerase (D-DT) inhibitor with an IC₅₀ value of 0.5 µM. RGB097 has the potential for the research of cancer.

HY-P99262

Imalumab	Inhibitor	98.37%
Imalumab (BAX69) is a recombinant, human IgG1 monoclonal antibody that targets macrophage inhibitory factor (MIF). Imalumab can be used for the research of ovarian carcinoma, recurrent malignant ascites and cancer.

HY-121356

Carebastine	Inhibitor	99.23%
Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner. Carebastine suppresses the expression of macrophage migration inhibitory factor.

HY-115887

R110	Inhibitor	99.90%
R110 is a potent, competitive inhibitor of macrophage migration inhibitory factor 2 (MIF2) tautomerase with an IC₅₀ of 15 μM. R110 has the potential for the research of cancer diseases.

HY-123814

4-CPPC	Inhibitor	99.64%
4-CPPC is a potent, reversible and selective MIF-2 inhibitor with K_i values of 431, 33 µM for MIF-1, MIF-2, respectively.

HY-W164560

RDR 03785	Inhibitor
RDR 03785 is a covalent MIF inhibitor with an IC₅₀ of 0.36 μM.

HY-110084

BTZO-1	Inhibitor	99.69%
BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a K_d value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.

HY-130332

Mitomycin A	Inhibitor
Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer.

HY-148117

MD13	Inhibitor
MD13 is a macrophage migration inhibitory factor (MIF)-directed PROTAC with a K_i of 71 nM. MD13 can be used for cancer research.

HY-149308

MKA031	Inhibitor
MKA031 (compound 6y) is a non-competitive MIF inhibitor with an IC₅₀ value of 1.7 μM. MKA031 (compound 6y) interferes with MIF/AIF interaction, MIF nuclear translocation, and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced dependent cell death. MKA031 can be used in the study of chronic hepatitis C virus infection.

HY-144194

MIF-IN-2	Inhibitor
MIF-IN-2 is a migration inhibitory factor (MIF) inhibitor extracted from patent WO2021258272A1 compound 1. MIF-IN-2 can be used for the research of immune inflammation-related diseases.

HY-144196

MIF-IN-4 hydrochloride	Inhibitor
MIF-IN-4 hydrochloride is potent macrophage migration inhibitory factor (MIF) inhibitor (pIC₅₀=5.01-6). MIF is a cytokine originally found to play a role in inhibiting macrophage migration.

HY-146319

MIF-IN-6	Inhibitor
MIF-IN-6 (compound 2d) is a potent macrophage migration inhibitory factor (MIF) inhibitor with an IC₅₀ of 1.4 μM and a K_i value of 0.96 μM, respectively. MIF-IN-6 attenuates MIF-induced ERK phosphorylation and inhibits proliferation of A549 cells.

HY-144190

MIF-IN-1	Inhibitor
MIF-IN-1 (compound 14) is a potent macrophage migration inhibitory factor (MIF) inhibitor (pIC₅₀=6.87).

HY-146318

MIF-IN-5	Inhibitor
MIF-IN-5 (compound 1d) is a potent and reversible macrophage migration inhibitory factor (MIF) competitive inhibitor with an IC₅₀ of 4.8 μM and a K_i value of 3.3 μM, respectively.

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