2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Malate Dehydrogenase (MDH)

Malate Dehydrogenase (MDH)

Malate Dehydrogenase

Malate Dehydrogenase (MDH) is an enzyme that plays a key role in cellular metabolism and belongs to the NAD-dependent dehydrogenase family. Malate Dehydrogenase (MDH) catalyzes the reversible conversion between malate and oxaloacetate. There are multiple subtypes of MDH. In eukaryotes, there are mainly cytoplasmic MDH1, mitochondrial MDH2, and MDH present in peroxisomes, glyoxysomes, and chloroplasts; there is only one MDH in prokaryotes such as Escherichia coli. MDH1 is closely related to the proliferation and survival of tumor cells, and its high expression is associated with a poor prognosis of non-small cell lung cancer. MDH1 plays an important role in replenishing cytoplasmic NAD to support glycolysis during cell proliferation, and together with lactate dehydrogenase (LDH), maintains the intracellular NAD supply; in cardiovascular disease research, it was found that changes in its activity are related to energy metabolism, oxidative stress and other processes in cardiac tissue. In addition, MDH participates in important metabolic pathways such as the tricarboxylic acid cycle, gluconeogenesis, and amino acid synthesis, and plays a role in different cellular compartments. For example, MDH transports reducing equivalents between the cytoplasm and mitochondria through the malate-aspartate shuttle, maintaining cellular energy metabolism and normal physiological functions[1][2][3][4][5][6].

Malate Dehydrogenase (MDH) Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W613220
    MDH1/2-IN-1
    		Inhibitor
    MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 nM and 1.06 nM respectively). MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism.
    MDH1/2-IN-1