2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Malate Dehydrogenase (MDH)
  5. Malate Dehydrogenase (MDH) Inhibitor

Malate Dehydrogenase (MDH) Inhibitor

Malate Dehydrogenase (MDH) Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-147791
    MDH1-IN-2
    		Inhibitor 98.70%
    MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 μM for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to α-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis.
  • HY-W613220
    MDH1/2-IN-1
    		Inhibitor
    MDH1/2-IN-1 is a MDH1/2 inhibitor (IC50: 1.07 nM and 1.06 nM respectively). MDH1/2-IN-1 inhibits mitochondrial respiration and the HIF-1α pathway. MDH1/2-IN-1 demonstrates significant anti-tumor potential. MDH1/2-IN-1 provides a new direction for the development of drugs targeting cancer metabolism.