2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide S Receptor
  5. Neuropeptide S Receptor Antagonist

Neuropeptide S Receptor Antagonist

Neuropeptide S Receptor Antagonists (2):

Cat. No. Product Name Effect Purity
  • HY-108625
    SHA 68
    		Antagonist 99.84%
    SHA 68 is a potent and selective non-peptide neuropeptide S receptor (NPSR) antagonist with IC50s of 22.0 and 23.8 nM for NPSR Asn107 and NPSR Ile107, respectively. SHA 68 has limited the blood-brain barrier (BBB) penetration and the activity in neuralgia.
  • HY-108626
    ML154
    		Antagonist 99.59%
    ML154 (NCGC84) is a selective, brain-penetrant and non-peptide neuropeptide S receptor (NPSR) antagonist with a pA2 of 9.98. ML154 potently inhibits NPS-stimulated cellular calcium, cAMP, and ERK phosphorylation responses with IC50 values of 36.5 nM, 22.1 nM, and 9.3 nM, respectively.