2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Nuclear Hormone Receptor 4A/NR4A
  5. Nuclear Hormone Receptor 4A/NR4A Inducer

Nuclear Hormone Receptor 4A/NR4A Inducer

Nuclear Hormone Receptor 4A/NR4A Isoform Comparison

Nuclear Hormone Receptor 4A/NR4A Inducer (1):

Cat. No. Product Name Effect Purity
  • HY-170849
    Nur77 modulator 4
    		Inducer
    Nur77 modulator 4 (Compound 15h) is a Nur77 inducer with a KD of 0.477 μM. Nur77 modulator 4 significantly induces Nur77 expression and apoptosis, showing excellent growth inhibition in HepG2 and MCF-7 cells, with an IC50 of less than 5 μM. Nur77 modulator 4 activates Nur77-mediated ER stress through the PERK-ATF4 and IRE1 signaling pathways, thereby inducing cell apoptosis. Nur77 modulator 4 can be used in cancer research applications .