2. Signaling Pathways
  3. Neuronal Signaling
  4. OGT
  5. OGT Inhibitor

OGT Inhibitor

OGT Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-119738
    OSMI-1
    		Inhibitor 99.90%
    OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
  • HY-114361
    OSMI-4
    		Inhibitor 99.55%
    OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
  • HY-136282
    OGT-IN-2
    		Inhibitor 99.82%
    OGT-IN-2 (compound 4) is a potent O-GlcNAc transferase (OGT) inhibitor, with IC50 values of 30 and 53 μM for sOGT and ncOGT, respectively.
  • HY-125278
    OGT-IN-4
    		Inhibitor
    OGT-IN-4 (compound 4a) is an O-GlcNAc transferase (OGT) inhibitor with a Kd of 8 nM. OGT-IN-4 can be utilized in OGT related research.
  • HY-135784
    OSMI-2
    		Inhibitor 98.73%
    OSMI-2 (Compound 1b) is a cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-2 increases detained intron splicing in cells.
  • HY-119738A
    (Rac)-OSMI-1
    		Inhibitor
    (Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.
  • HY-135785
    OSMI-3
    		Inhibitor
    OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells.