OGT-IN-2

Name: OGT-IN-2
Brand: MedChemExpress
SKU: HY-136282
Rating: 4.5 (1 reviews)

Cat. No.: HY-136282 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

OGT-IN-2 (compound 4) is a potent O-GlcNAc transferase (OGT) inhibitor, with IC₅₀ values of 30 and 53 μM for sOGT and ncOGT, respectively.

For research use only. We do not sell to patients.

OGT-IN-2 Chemical Structure

CAS No. : 442665-87-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 226	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 226	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 205	In-stock	Estimated Time of Arrival: December 31
10 mg		Get quote
50 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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ACAT1 ACAT2 MGAT2 ACAT

Biological Activity
Purity & Documentation
References
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Description

OGT-IN-2 (compound 4) is a potent O-GlcNAc transferase (OGT) inhibitor, with IC₅₀ values of 30 and 53 μM for sOGT and ncOGT, respectively^[1].

IC₅₀ & Target

IC50: 30 ± 2 μM (sOGT), 53 ± 7 μM (ncOGT)^[1]

Molecular Weight

446.99

Formula

C₂₃H₂₇ClN₂O₃S

CAS No.

442665-87-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1)N(/C(SC1C(O)=O)=N/C(C=C2)=CC=C2Cl)CCC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (279.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2372 mL	11.1859 mL	22.3719 mL
5 mM	0.4474 mL	2.2372 mL	4.4744 mL
10 mM	0.2237 mL	1.1186 mL	2.2372 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.08 mg/mL (4.65 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.65 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (252 KB) LCMS (93 KB)

Handling Instructions (2659 KB)

References

[1]. Gross BJ, et al. Discovery of O-GlcNAc transferase inhibitors. J Am Chem Soc. 2005 Oct 26;127(42):14588-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2372 mL	11.1859 mL	22.3719 mL	55.9297 mL
	5 mM	0.4474 mL	2.2372 mL	4.4744 mL	11.1859 mL
	10 mM	0.2237 mL	1.1186 mL	2.2372 mL	5.5930 mL
	15 mM	0.1491 mL	0.7457 mL	1.4915 mL	3.7286 mL
	20 mM	0.1119 mL	0.5593 mL	1.1186 mL	2.7965 mL
	25 mM	0.0895 mL	0.4474 mL	0.8949 mL	2.2372 mL
	30 mM	0.0746 mL	0.3729 mL	0.7457 mL	1.8643 mL
	40 mM	0.0559 mL	0.2796 mL	0.5593 mL	1.3982 mL
	50 mM	0.0447 mL	0.2237 mL	0.4474 mL	1.1186 mL
	60 mM	0.0373 mL	0.1864 mL	0.3729 mL	0.9322 mL
	80 mM	0.0280 mL	0.1398 mL	0.2796 mL	0.6991 mL
	100 mM	0.0224 mL	0.1119 mL	0.2237 mL	0.5593 mL

OGT-IN-2 Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OGT-IN-2442665-87-4OGTAcyltransferaseO-linked N-acetylglucosaminyltransferaseO-GlcNAc transferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasearticular diseasesarticular cartilageosteoarthritisInhibitorinhibitorinhibit

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OGT-IN-2

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OGT-IN-2 Related Antibodies

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References

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Complete Stock Solution Preparation Table

OGT-IN-2 Related Classifications

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