2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. PANK
  5. PANK Modulator

PANK Modulator

PANK Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-124634
    PZ-2891
    		Modulator 99.38%
    PZ-2891 is an orally bioavailable, brain penetrant pantothenate kinase (PANK) modulator. PZ-2891 act as an orthosteric inhibitor at high concentrations and an allosteric activator at lower sub-saturating concentrations. PZ-2891 inhibits human pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of 40.2 nM, 0.7 nM and 1.3 nM, respectively.
  • HY-159509
    Claziprotamidum
    		Modulator
    Claziprotamidum (Claziprotamide) is a pantothenate kinases 1 and 3 (PanK1 and PanK3) positive allosteric modulator (PAM).