2. Signaling Pathways
  3. GPCR/G Protein
  4. Platelet-activating Factor Receptor (PAFR)
  5. Platelet-activating Factor Receptor (PAFR) Inhibitor

Platelet-activating Factor Receptor (PAFR) Inhibitor

Platelet-activating Factor Receptor (PAFR) Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-P2606
    Antiflammin 2
    		Inhibitor 99.50%
    Antiflammin 2 inhibits the synthesis of platelet-activating factor (PAF) with the IC50 of 100 nM.
  • HY-N3643
    Cryptomeridiol
    		Inhibitor
    Cryptomeridiol is a platelet-activating factor (PAF) receptor binding inhibitor. Cryptomeridiol has melanogenesis inhibitory activity in the α-MSH (HY-P0252)-stimulated B16 melanoma cells.
  • HY-117811
    (R,R)-MK 287
    		Inhibitor
    (R,R)-MK 287 is a tetrahydrofuran derivative that potently inhibits [3H]C18-PAF binding to human platelets, polymorphonuclear leukocytes (PMNs), and lung membranes with Ki values ??of 6.1, 3.2, and 5.49 nM, respectively. [3H]MK 287 binds to human platelet and PMN membranes with KD values ??of 2.1 and 2.9 nM. When tested on isolated human cells, MK 287 potently and selectively inhibits PAF-induced platelet aggregation (ED50=56 nM or ED50=1.5 nM for gel-filtered platelets) and elastase release from PMNs (ED50=4.4 nM). In in vivo studies, MK 287 inhibited PAF-induced lethality in mice (ED50=0.8 mg/kg, po) and PAF-induced bronchospasm in guinea pigs (ED50=0.18 mg/kg).
  • HY-N9300
    1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan
    		Inhibitor
    1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan, a lignan derivative from the ethyl acetate soluble fraction of twigs of Magnolia denudate (Magnoliaceae), exhibits anti-platelet-activating factor (PAF) activity. PAF is a potent lipid mediator in inflammation and asthma.
  • HY-118779
    Rhazimine
    		Inhibitor
    Rhazimine is an indole alkaloid that is a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation.
  • HY-N11932
    Piperulin A
    		Inhibitor
    Piperulin A is a potent inhibitor of PAFR. Piperulin A inhibits the specific binding of PAFR on isolated rabbit platelet plasma membranes with an IC50 of 7.3 μM.
  • HY-N3054
    Pinusolidic acid
    		Inhibitor
    Pinusolidic acid is a platelet-activating factor (PAF) inhibitor with an IC50 of 23 μM.