Pinusolidic acid

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Pinusolidic acid is a platelet-activating factor (PAF) inhibitor with an IC₅₀ of 23 μM.

For research use only. We do not sell to patients.

Pinusolidic acid Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

Pinusolidic acid is a platelet-activating factor (PAF) inhibitor with an IC₅₀ of 23 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 40 μM Compound: 21	Cytotoxicity against human A549 cells after 48 hrs by MTT assay Cytotoxicity against human A549 cells after 48 hrs by MTT assay	[PMID: 23691952]
HL-60	IC₅₀	> 40 μM Compound: 21	Cytotoxicity against human HL60 cells after 48 hrs by MTT assay Cytotoxicity against human HL60 cells after 48 hrs by MTT assay	[PMID: 23691952]
MCF7	IC₅₀	> 40 μM Compound: 21	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 23691952]
SMMC-7721	IC₅₀	> 40 μM Compound: 21	Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay Cytotoxicity against human SMMC7721 cells after 48 hrs by MTT assay	[PMID: 23691952]
SW480	IC₅₀	> 40 μM Compound: 21	Cytotoxicity against human SW480 cells after 48 hrs by MTT assay Cytotoxicity against human SW480 cells after 48 hrs by MTT assay	[PMID: 23691952]
Vero	CC₅₀	> 750 μM Compound: 9	Cytotoxicity against Vero E6 cells by MTT assay Cytotoxicity against Vero E6 cells by MTT assay	[PMID: 17663539]
Vero	EC₅₀	4.71 μM Compound: 9	Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA Antiviral activity against SARS coronavirus in Vero E6 cells assessed as inhibition of viral replication by ELISA	[PMID: 17663539]

Molecular Weight

332.43

Formula

C₂₀H₂₈O₄

CAS No.

40433-82-7

SMILES

C[C@@]12[C@](CCC([C@@H]2CCC3=CCOC3=O)=C)([H])[C@](C)(CCC1)C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Microorganisms

Antrodia camphorata

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. H O Yang, et al. Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis. Planta Med. 1998 Feb;64(1):72-4. [Content Brief]