2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Protein Prenyltransferase
  5. Protein Prenyltransferase Inhibitor

Protein Prenyltransferase Inhibitor

Protein Prenyltransferase Inhibitors (2):

Cat. No. Product Name Effect Purity
  • HY-115489A
    GGTI-286 TFA
    		Inhibitor
    GGTI-286 TFA, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent (IC50=2 μM) than the corresponding methyl ester of FTI-276 (HY-15873A). GGTI-286 TFA selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s=2 and >30 μM, respectively). GGTI-286 TFA also potently inhibits oncogenic K-Ras4B stimulation with an IC50 of 1 μM.
  • HY-120229
    GGTI-2147
    		Inhibitor
    GGTI-2147 is a potent GGTase I inhibitor. GGTI-2147 blocks geranyl-geranylation of Rap1A and reduces the activity of Rac1 (one of substrates for GGTI) and ameliorates the OGD/R-induced neuronal apoptosis.GGTI-2147 can be used for neurodevelopmental disorders research, such as autism, depression, and schizophrenia.