2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Pyruvate Carboxylase (PC)

Pyruvate Carboxylase (PC)

Pyruvate Carboxylase

Pyruvate carboxylase (PC) is a biotin-dependent mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a critical step in the tricarboxylic acid (TCA) cycle. It typically functions as a tetramer composed of four identical subunits, each with a molecular weight of approximately 120-130 kDa. PC is essential for various anabolic processes, including gluconeogenesis, lipogenesis, insulin secretion, and the synthesis of glutamate neurotransmitters[1].

In cancer cells, PC plays a pivotal role in metabolic reprogramming and adaptation, contributing to lipid metabolism and protection against oxidative stress. Clinically, pyruvate carboxylase deficiency is a rare metabolic disorder characterized by lactic acidemia, encephalopathy, and prominent neurological symptoms during the neonatal and infantile periods. This highlights PC's critical role in energy metabolism and brain function[2].

Pyruvate Carboxylase (PC) Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-142870
    ZY-444
    		Inhibitor 98.70%
    ZY-444 is a small molecule that suppresses breast cancer progression by targeting pyruvate carboxylase.
    ZY-444
  • HY-161680
    Pyruvate Carboxylase-IN-4
    		Inhibitor
    Pyruvate Carboxylase-IN-4 (Compd 8V) is a potent and competitive Pyruvate Carboxylase inhibitor with an IC50 of 4.3 μM.
    Pyruvate Carboxylase-IN-4
  • HY-163771
    Pyruvate Carboxylase-IN-5
    		Inhibitor
    Pyruvate Carboxylase-IN-5 (compound 6m) is a pyruvate carboxylase inhibitor with high selectivity and permeability. Pyruvate carboxylase is a mitochondrial enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate, a process that plays an important role in maintaining steady-state levels of Krebs cycle intermediates, which are precursors for the synthesis of biomacromolecules such as amino acids, fatty acids, and glucose.
    Pyruvate Carboxylase-IN-5