2. Signaling Pathways
  3. NF-κB
  4. RANKL/RANK

RANKL/RANK

Receptor activator of NF-κB (RANK) and its ligand receptor activator of NF-κB ligand (RANKL) are encoded, respectively, by the Tumor necrosis factor receptor superfamily member 11A (Tnfrsf11a) and the Tumor necrosis factor ligand superfamily member 11 (Tnfsf11) genes, RANK and RANKL constitute a receptor-ligand pair initiating a signaling pathway of paramount relevance in bone remodeling, lymph node formation, establishment of the thymic microenvironment, mammary gland development during pregnancy, and bone metastasis in cancer. RANK mutant mice, as well as RANKL mutant mice, exhibit severe osteopetrosis and defective tooth eruption due to a complete lack in osteoclast. Moreover, RANKL and RANK mutant mice lack lymph nodes and AIRE+ thymic medullary epithelial cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-169857A
    AS2690168 hydrochloride
    		Inhibitor
    AS2690168 hydrochloride is an orally active RANKL signal transduction inhibitor which suppresses RANKL-induced osteoclastogenesis of RAW264 cells. AS2690168 can be utilized in research related to pathological osteolysis.
    AS2690168 hydrochloride
  • HY-168090
    Anti-osteoporosis agent-11
    Anti-osteoporosis agent-11 (compound 3k) is an anti-osteoporosis compound targeting osteoclasts. Anti-osteoporosis agent-11 has the most significant inhibitory effect on osteoclast differentiation, with an IC50 value of 0.36 μM. In addition, Anti-osteoporosis agent-11 inhibits osteoclast formation, bone resorption, and the expression of osteoclast-specific genes by blocking rankl-induced mitogen-activated protein kinase (MAPK) and NF-κB signaling pathways.
    Anti-osteoporosis agent-11
  • HY-N0499R
    Cyanidin (Chloride) (Standard)
    Cyanidin (Chloride) (Standard) is the analytical standard of Cyanidin (Chloride). This product is intended for research and analytical applications. Cyanidin Chloride (IdB 1027), a subclass of anthocyanin, displays antioxidant and anti-carcinogenesis properties. Cyanidin Chloride (IdB 1027) inhibits osteoclast formation, hydroxyapatite resorption, and receptor activator of NF-κB ligand (RANKL)-induced osteoclast marker gene expression.
    Cyanidin (Chloride) (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity