2. Signaling Pathways
  3. Immunology/Inflammation
  4. SOD

SOD

Superoxide Dismutase

SOD (Superoxide dismutase), an antioxidant enzyme, are a group of metalloenzymes that defenses against reactive oxygen species (ROS)-mediated injury. SOD can catalyze the dismutation of superoxide radicals (O2˙-) into hydrogen peroxide (H2O2) and oxygen (O2). The chemical moiety of SOD contains some metal ions such as Cu2+, Zn2+, Mn2+, and Fe2+ in the active site, which mediates the dismutation process. On the basis of these metallic cofactors, SOD can be classified into three distinct types, SOD1 (Cu/Zn-SOD), SOD2 (Mn-SOD), and SOD3 (Fe-SOD)[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-129782
    SC-55858
    SC-55858 is an effective superoxide dismutase simulator. SC-55858 increased heart rate and decreased mean arterial pressure and left ventricular systolic and end-diastolic pressures in conscious dogs.
    SC-55858
  • HY-W022973
    Trinexapac-ethyl
    		Activator
    Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator.
    Trinexapac-ethyl
  • HY-129064A
    Superoxide Dismutase, Human Erythrocyte
    Superoxide Dismutase (SOD), widely distributed in aerobic organisms, catalyzes dismutation of the superoxide free radical, O2-, to oxygen and hydrogen peroxide and apparently protects against oxygen toxicity. In human erythrocytes, O2- arises from autoxidation of oxyhemoglobin and SOD activity is copper-dependent.
    Superoxide Dismutase, Human Erythrocyte
  • HY-P2005
    Malformin C
    		Inhibitor
    Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content.
    Malformin C
  • HY-Y0682AR
    Ethylenediaminetetraacetic acid disodium dihydrate (Standard)
    		Activator
    Ethylenediaminetetraacetic acid (disodium dihydrate) (Standard) is the analytical standard of Ethylenediaminetetraacetic acid (disodium dihydrate). This product is intended for research and analytical applications. Ethylenediaminetetraacetic acid (EDTA) disodium dehydrate is a kind of metal chelating agent (binds to bivalent and trivalent metal cations, including calcium). Ethylenediaminetetraacetic acid disodium dehydrate has antibacterial, anti-inflammatory, antioxidant, anti-hypercalcemia and anticoagulant activities. Ethylenediaminetetraacetic acid disodium dehydrate decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid disodium dehydrate can alleviate the liver fibrosis. Ethylenediaminetetraacetic acid disodium dehydrate can be used for coronary artery disease and neural system disease research[4].
    Ethylenediaminetetraacetic acid disodium dihydrate (Standard)
  • HY-E70377
    Cu/Zn Superoxide dismutase
    Cu/Zn Superoxide dismutase (Cu/Zn SOD; SOD1) is a cytosolic copper-zinc dimer form of superoxide dismutase enzyme. Cu/Zn Superoxide dismutase has oxygen radical enzymatic dismutation.
    Cu/Zn Superoxide dismutase
  • HY-169904
    AKV-9
    		Inhibitor 99.98%
    AKV-9 is the inhibitor for mutated Cu/Zn superoxide dismutase (SOD1), that inhibits SOD1-induced protein aggregation and exhibits protective efficacy against SOD1-induced cytotoxicity in PC-12 with an EC50 of 0.3 μM. AKV-9 ameliorates amyotrophic lateral sclerosis in mouse models and extends their lifespan.
    AKV-9
  • HY-158205
    HPO-DAEE
    HPO-DAEE (4-Hydroperoxy-2-decenoic acid ethyl ester) elicits nuclear accumulation of Nrf2 and activated antioxidant response element (ARE). HPO-DAEE induces antioxidant genes upregulation (eg: HO-1) through Nrf2-ARE signaling. HPO-DAEE induces reactive oxygen species generation. HPO-DAEE also inhibits histone deacetylase and upregulate expression of extracellular superoxide dismutase via histone acetylation. HPO-DAEE protects against 6-hydroxydopamine-induced cell death via activation of Nrf2-ARE and eIF2α-ATF4 pathways.
    HPO-DAEE
  • HY-116117
    Salicylcurcumin
    		Modulator
    Salicylcurcumin is a synthetic curcumin analogue with antioxidant activity. Salicylcurcumin may affect lipid peroxidation in fish, favoring increased survival, disease resistance, and ultimately growth rate.
    Salicylcurcumin
  • HY-N0638R
    Dendrobine (Standard)
    		Activator
    Dendrobine (Standard) is the analytical standard of Dendrobine. This product is intended for research and analytical applications. Dendrobine is an alkaloid isolated from Dendrobium nobile. Dendrobine possesses antiviral activity against influenza A viruses, with IC50s of 3.39 μM, 2.16 μM and 5.32 μM for A/FM-1/1/47 (H1N1), A/Puerto Rico/8/34 H274Y (H1N1) and A/Aichi/2/68 (H3N2), respectively.
    Dendrobine (Standard)
  • HY-14744B
    Levamlodipine hydrochloride
    		Activator
    Levamlodipine hydrochloride (Levoamlodipine hydrochloride) is a dihydropyridine calcium channel blocker. Levamlodipine hydrochloride reduces the inflow of calcium ions by blocking L-type calcium channels on vascular smooth muscle cells, thereby leading to vasodilation, lower blood pressure and lighten the burden on the heart. Levamlodipine hydrochloride has activity to lower blood pressure and relieve angina. The binding properties of Levamlodipine hydrochloride to human serum albumin (HSA) contribute to the study of drug transport and release mechanisms in the body.
    Levamlodipine hydrochloride
  • HY-P1512
    Antioxidant peptide A
    Antioxidant peptide A is a short peptide, which contains alternative aromatic or sulfur-containing amino acid. The side chains of Antioxidant peptide A are believed to contribute to strong radical scavenging activities of peptides in the cancer cell.
    Antioxidant peptide A
  • HY-170798
    Monoamine Oxidase B inhibitor 6
    Monoamine Oxidase B inhibitor 6 (Compound BT5) is a BBB-penatrable, highly selective, reversible and competitive MAO-B inhibitor, with an IC50 of 0.11 μM. Monoamine Oxidase B inhibitor 6 has antioxidant and neuroprotective effects and can be used in the research of neurodegenerative diseases.
    Monoamine Oxidase B inhibitor 6
  • HY-W017960R
    Diludine (Standard)
    		Activator
    Diludine (Standard) is the analytical standard of Diludine. This product is intended for research and analytical applications. Diludine has antioxidant properties, targeting oxidative stress-related pathways. By improving antioxidative status and reducing β-hydroxybutyrate levels, Diludine alleviates oxidative stress during the parturition period in dairy cows. It is primarily used during the transition period in dairy cows to increase milk yield and milk fat content, as well as to improve health during parturition.
    Diludine (Standard)
  • HY-14744C
    Levamlodipine hydrobromide
    		Activator
    Levamlodipine hydrobromide is the besylate hydrobromide salt form of Levamlodipine (HY-14744). Levamlodipine hydrobromide is an orally active calcium channel blocker with antioxidant and vasodilatory properties. Levamlodipine hydrobromide can reduce serum malondialdehyde (MDA) levels, increase superoxide dismutase (SOD) activity, and improve oxidative stress. Levamlodipine hydrobromide can be used for research on vascular dementia, hypertension, and cerebrovascular diseases.
    Levamlodipine hydrobromide
  • HY-130438
    EUK-118
    EUK-118 is an analog of EUK 8 and EUK 134 with reduced activity. EUK-118 exhibits superoxide dismutase (SOD) mimetic activity.
    EUK-118
  • HY-W268542R
    4-Acetylaminoantipyrine (Standard)
    		Inhibitor
    4-Acetylaminoantipyrine (Standard) is the analytical standard of 4-Acetylaminoantipyrine. This product is intended for research and analytical applications. 4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation.
    4-Acetylaminoantipyrine (Standard)
  • HY-P1501
    δ-Sleep Inducing Peptide
    δ-Sleep Inducing Peptide is a neuropeptide, with antioxidant and anxiolytic properties.
    δ-Sleep Inducing Peptide
  • HY-130439
    EUK-124
    EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC50 values of 5 μM and 0.7 μM, respectively.
    EUK-124
  • HY-N0160R
    Kinetin (Standard)
    Kinetin (Standard) is the analytical standard of Kinetin. This product is intended for research and analytical applications. Kinetin (N6-furfuryladenine) belongs to the family of N6-substituted adenine derivatives known as cytokinins, which are plant hormones involved in cell division, differentiation and other physiological processes. Kinetin has anti-aging effects.
    Kinetin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity