2. Signaling Pathways
  3. Neuronal Signaling
  4. Transthyretin (TTR)

Transthyretin (TTR)

thyroxine-binding prealbumin

Transthyretin (TTR), formerly known as thyroxine-binding prealbumin, is a tetrameric protein transporting hormones in the plasma and brain. It forms a complex with retinol-binding protein (RBP), which facilitates the transport of thyroid hormones and vitamin A in the blood and cerebrospinal fluid. TTR is a positive indicator of nutrition status and is negatively correlated with inflammation. TTR is a neuroprotective and oxidative-stress-suppressing factor. The TTR structure is destabilized by mutations, oxidative modifications, aging, proteolysis, and metal cations, including Ca2+. Destabilized TTR molecules form amyloid deposits, resulting in senile and familial amyloidopathies.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-146137
    Transthyretin-IN-1
    Transthyretin-IN-1 (Compound 1d) is a transthyretin (TTR) fibril formation inhibitor. Transthyretin-IN-1 can be used for Alzheimer’s disease research.
    Transthyretin-IN-1
  • HY-P10615
    Abz-YGGRASDQ-EDDnp
    Abz-YGGRASDQ-EDDnp is a fluorescent substrate of transthyretin (TTR) protein and is used to detect the hydrolytic activity of TTR protein.
    Abz-YGGRASDQ-EDDnp
  • HY-132590
    Revusiran
    Revusiran (ALN-TTRSC) is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran can be used for transthyretin (TTR)-mediated amyloidosis research.
    Revusiran
  • HY-N1957R
    Gamma-Mangostin (Standard)
    		Inhibitor
    Gamma-Mangostin (Standard) is the analytical standard of Gamma-Mangostin. This product is intended for research and analytical applications. Gamma-Mangostin is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptor antagonist and potent epoxidase 2 (COX-2) inhibitor, as well as a transthyroxin protein (TTR) profibrosis inhibitor. Gamma-Mangostin binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 μM). Gamma-Mangostin has anti-inflammatory, antibacterial, antioxidant and anticancer activities, and can be used in the study of metabolic disorders such as diabetes.
    Gamma-Mangostin (Standard)
  • HY-P990734
    Coramitug
    		Inhibitor
    Coramitug is an anti-TTR human IgG1 κ monoclonal antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).
    Coramitug
  • HY-160612
    Transthyretin-IN-2
    		Inhibitor
    Transthyretin-IN-2 (Compound 36) is a transthyretin (TTR) amyloidsis inhibitor, with IC50 and pIC50 values of 1.31 μM and 5.88 μM. Transthyretin-IN-2 can be used for the research of TTR amyloidosis diseases.
    Transthyretin-IN-2
Cat. No. Product Name / Synonyms Application Reactivity