2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Urea Transporter
  5. Urea Transporter Inhibitor

Urea Transporter Inhibitor

Urea Transporter Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-128129
    UT-B-IN-1
    		Inhibitor 99.68%
    UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
  • HY-155642
    PU-48
    		Inhibitor 99.64%
    PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic.
  • HY-121132
    Butibufen
    		Inhibitor
    Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.
  • HY-168434
    Urease-IN-19
    		Inhibitor
    Urease-IN-19 (Compound 3c) is a potent urease inhibitor with an IC50 value of 2.7 µM. Urease-IN-19 is promising for research of kidney stones and stomach ulcers.
  • HY-131382
    UTA1inh-C1
    		Inhibitor
    UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC50 of 4.2 μM.