2. Signaling Pathways
  3. Anti-infection
  4. Virus Protease

Virus Protease

Virus Protease

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Viral proteases are enzymes encoded by the genetic material (DNA or RNA) of viral pathogens. Viral proteases catalyze the cleavage of specific peptide bonds in viral polyprotein precursors or in cellular proteins. Viral proteases may use different catalytic mechanisms involving either serine, cysteine or aspartic acid residues to attack the scissile peptide bond. Selective recognition of these sequence patterns by a complementary substrate binding site of the enzyme ensures a high degree of specific recognition and cleavage.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the cause of the respiratory illness coronavirus disease 2019 (COVID-19). Initial spike protein priming by transmembrane protease, serine 2 (TMPRSS2) is essential for entry of SARS-CoV-2. After a SARS-CoV-2 virion attaches to a target cell, the cell's protease TMPRSS2 cuts open the spike protein of the virus, exposing a fusion peptide.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108325S
    Brequinar-d3
    		Inhibitor
    Brequinar-d3 (DUP785-d3) is deuterium labeled Brequinar. Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.
    Brequinar-d<sub>3</sub>
  • HY-170599
    H117
    		Inhibitor 99.27%
    H117 is a PROTAC target protein ligand that can be used to synthesize PROTAC HP211206 (HY-170598). H117 has competitive binding and inhibition ability on SARS-CoV-2 main protease (Mpro) with an IC50 of 151.3 nM.
    H117
  • HY-170399
    SARS-CoV-2 PLpro-IN-1
    		Inhibitor
    SARS-CoV-2 PLpro-IN-1 (Compound 85) is a non-covalent and competitive inhibitor of SARS-CoV-2 PLpro with an IC50 of 15.06 μM and a Ki of 22.93 μM. SARS-CoV-2 PLpro-IN-1 inhibits the proliferation of Vero cell with an IC50 of 7.47 μM.
    SARS-CoV-2 PLpro-IN-1
  • HY-N14925
    Citrinin hydrate
    		Inhibitor
    Citrinin hydrate is a human rhinovirus 3C protease inhibitor with the IC50 of 1.0 mM.
    Citrinin hydrate
  • HY-B0448S2
    Phenytoin-d5
    		Inhibitor
    Phenytoin-d5 (5,5-Diphenylhydantoin-d5) is deuterium labeled Phenytoin. Phenytoin (5,5-Diphenylhydantoin) is a potent Voltage-gated Na+ channels (VGSCs) blocker. Phenytoin has antiepileptic activity and reduces breast tumour growth and metastasis in mice.
    Phenytoin-d<sub>5</sub>
  • HY-173305
    Mpro/PLPro-IN-2
    		Inhibitor
    Mpro/PLPro-IN-2 (Compound 22l) is a non-covalent competitive dual inhibitor of the papain-like protease and main protease of SARS-CoV-2, with a Ki of 0.2 μM for the papain-like protease and a Ki of 1.1 μM for the main protease. Mpro/PLPro-IN-2 can be used in the research field of anti-SARS-CoV-2.
    Mpro/PLPro-IN-2
  • HY-P991153
    Potravitug
    		Inhibitor
    Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation.
    Potravitug
  • HY-173199
    PRRSV-IN-1
    		Inhibitor
    PRRSV-IN-1 (Compound 4s) is a nsp4 protease inhibitor targeting PRRSV, exhibiting an EC50 of 0.45 μM against PRRSV. It binds to the nsp4 protease with a Kd value of 29.24 pM and inhibits nsp4 protease activity with an IC50 of 80.36 pM. PRRSV-IN-1 can be used for research in the field of antiviral infections.
    PRRSV-IN-1
  • HY-158763
    MPI8
    		Inhibitor
    MPI8 (TG0205221) is an inhibitor of the major protease of SARS-CoV-2 (MPro) with high antiviral activity. MPI8 exerts its antiviral effect by dual and selective inhibition of SARS-CoV-2 MPro and host cell cysteine protease L (cathepsin L). This dual inhibition enhanced the overall antiviral potency and effect of MPI8. MPI8 can be used in clinical studies of COVID-19.
    MPI8
  • HY-N0469A
    L-Lysine (sulfite)
    		Inhibitor
    L-lysine sulfite is an essential amino acid for humans, offers numerous benefits and can be used in herpes research. Additionally, L-lysine sulfite enhances calcium absorption, reduces diabetes-related complications, improves gut health, and alleviates pancreatitis inflammation.
    L-Lysine (sulfite)
  • HY-158935
    Dihydro K22
    		Inhibitor
    Dihydro K22 is a derivative of the antiviral agent K22 (HY-122668).
    Dihydro K22
  • HY-N0354R
    Anthraquinone (Standard)
    		Inhibitor
    Anthraquinone (Standard) is the analytical standard of Anthraquinone. This product is intended for research and analytical applications. Anthraquinone is used as a precursor for dye formation.
    Anthraquinone (Standard)
  • HY-169102
    CHIKV nsP2 protease-IN-1
    		Inhibitor
    CHIKV nsP2 protease-IN-1(compound J13) is an oral active non-structural protein 2 protease inhibitor with the EC50 of 0.39 μM aganist of CHIKV S27. CHIKV nsP2 protease-IN-1 can be used for study of Chikungunya virus.
    CHIKV nsP2 protease-IN-1
  • HY-B0182R
    Carmofur (Standard)
    		Inhibitor
    Carmofur (Standard) is the analytical standard of Carmofur. This product is intended for research and analytical applications. Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA). Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI).
    Carmofur (Standard)
  • HY-10467
    HCV-796 analog
    		Inhibitor
    HCV-796 analog is a potent NS5B inhibitor that binds to the palm II site. HCV-796 analog is promising for research of hepatitis C (HCV) infections.
    HCV-796 analog
  • HY-170886
    SARS-CoV-2 Mpro-IN-36
    		Inhibitor
    SARS-CoV-2 Mpro-IN-36 (Compound 6d) is an inhibitor of SARS-CoV-2 Mpro with an IC50 of 110 nM. SARS-CoV-2 Mpro-IN-36 exhibits antiviral activity with an EC50 of 1.6 μM.
    SARS-CoV-2 Mpro-IN-36
  • HY-106312
    Viroxime
    Viroxime is an antiviral agent.
    Viroxime
  • HY-N15268
    Koenine
    		Inhibitor
    Koenine is a carbazole alkaloid. It is predicted that Koenine has strong binding affinity and inhibitory ability to SARS-CoV-2 main protease (Mpro), which can be used in the research of anti-novel coronavirus drugs.
    Koenine
  • HY-170504
    ZHAWOC25153
    		Inhibitor
    ZHAWOC25153 (Compound 17o) is a SARS-CoV-2 papain-like cysteine protease (PLpro) inhibitor, with an IC50 of 7 μM. ZHAWOC25153 exhibits antiviral activity and can be used in research within the field of anti-infection.
    ZHAWOC25153
Cat. No. Product Name / Synonyms Application Reactivity