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  2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Zinc Finger Protein

Zinc Finger Protein

Zinc Finger Protein

Zinc Finger Proteins (ZFPs) comprise the largest family of transcription factors, characterized by finger-like DNA-binding domains. The zinc-finger domain is one of the most common DNA-binding motifs found in eukaryotic transcriptional regulators. The most prevalent types of zinc-finger domain proteins include C2H2 (e.g., ZNF217), RING (e.g., E3-ubiquitin ligase), PHD (e.g., KDM2A), and LIM (e.g., Lin-11, Isl-1, and Mec-3) types. ZFPs are capable of interacting with DNA, RNA, poly-ADP-ribose (PAR), and other proteins, thereby facilitating diverse roles in cellular functions such as cell differentiation, apoptosis, transcriptional regulation, metabolism, and immune responses.

ZFPs, including ZNF281, ZNF750, ZNF185, and ZBP89, are implicated in tumorigenesis, cancer progression, and metastasis formation, highlighting their significance in oncogenic processes[1].

Zinc Finger Protein Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155539
    Cisd2 agonist 2
    		Agonist 99.17%
    Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters.
    Cisd2 agonist 2
  • HY-120264
    YPC-22026
    		Inhibitor
    YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities.
    YPC-22026