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  4. YPC-22026

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities.

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YPC-22026 Chemical Structure

YPC-22026 Chemical Structure

CAS No. : 1964457-41-7

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YPC-22026 Related Antibodies

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Description

YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC50 value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities[1].

In Vitro

YPC‐22026 (96 h) shows cytotoxic to HCT116 and PC‐3 with IC50 values of 0.33 μM and 0.66 μM, respectively[1].
YPC‐22026 (3 μM; 24 h) induces G2/M arrest and decreases the binding of ZNF143 to the STAF binding site[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

YPC-22026 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT116 cells
Concentration: 3 μM
Incubation Time: 24 h
Result: Induced G2/M arrest.
In Vivo

YPC‐22026 (50-100 mg/kg; i.p; on days 1, 2, 3, 8, 9, 12, and 16) significantly inhibits the growth of tumors in the HCT116 xenograft model[1].
In the PC‐3 xenograft model, YPC‐22026 (75 mg/kg; ip) significantly decreases in the intratumoral expression levels of all ZNF143 target genes, RAD51, PLK1, and Survivin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six‐week‐old male BALB/c nude mice injected with HCT116 cells[1]
Dosage: 50 mg/kg and 100 mg/kg
Administration: i.p; on days 1, 2, 3, 8, 9, 12, and 16 (50 mg/kg ); on days 1, 2, 3, 12, and 16 (100 mg/kg)
Result: Significantly inhibited the growth of tumors.
Molecular Weight

331.25

Formula

C16H8F3N3O2
CAS No.
SMILES

FC(F)(F)OC1=CC=CC=C1C2=NN=C(C#CC3=CC=CN=C3)O2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YPC-22026 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YPC-220261964457-41-7YPC22026YPC 22026Otherstumor regression inducerZNF143 inhibitoranti‐tumor activitiesRAD51PLK1SurvivinInhibitorinhibitorinhibit

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