2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Tetracaine hydrochloride

Tetracaine hydrochloride  (Synonyms: Amethocaine hydrochloride)

Cat. No.: HY-B0473 Purity: 99.91%
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Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic.

For research use only. We do not sell to patients.

Tetracaine hydrochloride Chemical Structure

Tetracaine hydrochloride Chemical Structure

CAS No. : 136-47-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Tetracaine hydrochloride:

Tetracaine hydrochloride Related Antibodies

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Description

Tetracaine hydrochloride (Amethocaine hydrochloride) is a calcium channel protein inhibitor and blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum. Tetracaine hydrochloride is mainly used topically in ophthalmology and as an antipruritic[1][2].

In Vitro

Tetracaine hydrochloride (Amethocaine hydrochloride) is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine hydrochloride is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetracaine hydrochloride Related Antibodies
Molecular Weight

300.82

Formula

C15H25ClN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(NCCCC)C=C1)OCCN(C)C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (166.21 mM; Need ultrasonic)

DMSO : ≥ 30 mg/mL (99.73 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3242 mL 16.6212 mL 33.2425 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

COA (242 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.3242 mL 16.6212 mL 33.2425 mL 83.1062 mL
5 mM 0.6648 mL 3.3242 mL 6.6485 mL 16.6212 mL
10 mM 0.3324 mL 1.6621 mL 3.3242 mL 8.3106 mL
15 mM 0.2216 mL 1.1081 mL 2.2162 mL 5.5404 mL
20 mM 0.1662 mL 0.8311 mL 1.6621 mL 4.1553 mL
25 mM 0.1330 mL 0.6648 mL 1.3297 mL 3.3242 mL
30 mM 0.1108 mL 0.5540 mL 1.1081 mL 2.7702 mL
40 mM 0.0831 mL 0.4155 mL 0.8311 mL 2.0777 mL
50 mM 0.0665 mL 0.3324 mL 0.6648 mL 1.6621 mL
60 mM 0.0554 mL 0.2770 mL 0.5540 mL 1.3851 mL
80 mM 0.0416 mL 0.2078 mL 0.4155 mL 1.0388 mL
H2O 100 mM 0.0332 mL 0.1662 mL 0.3324 mL 0.8311 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Tetracaine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetracaine136-47-0AmethocaineCalcium ChannelCa2+ channelsCa channelscalciumchannelproteinvoltage-sensitivereleaseCa2+sarcoplasmicreticulumInhibitorinhibitorinhibit

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