(±)-Stylopine (Synonyms: Tetrahydrocoptisine)

Cat. No.: HY-N0924 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities.

For research use only. We do not sell to patients.

(±)-Stylopine Chemical Structure

CAS No. : 4312-32-7

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (±)-Stylopine:

(-)-Stylopine Get quote
(±)-Stylopine hydrochloride Get quote

1 Publications Citing Use of MCE (±)-Stylopine

•Planta Med. 2024 Jun;90(7-08):523-533. [Abstract]

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Biological Activity
Purity & Documentation
References
Customer Review

Description

(±)-Stylopine (Tetrahydrocoptisine) is an alkaloid compound originally isolated from Corydalis tubers that exhibits anti-inflammatory and anti-parasitic activities^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
GES1	IC₅₀	> 150 μM Compound: 1	Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human GES1 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 35286954]
HGC-27	IC₅₀	55.06 μM Compound: 1	Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human HGC-27 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 35286954]
MGC-803	IC₅₀	107.3 μM Compound: 1	Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay Antiproliferative activity against human MGC-803 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 35286954]

Molecular Weight

323.34

Formula

C₁₉H₁₇NO₄

CAS No.

4312-32-7

Appearance

Solid

Color

White to off-white

SMILES

C1(C(CCN2CC3=C4OCOC4=CC=C3CC21)=C5)=CC6=C5OCO6

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMF : 4 mg/mL (12.37 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2.5 mg/mL (7.73 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Acetone : 1 mg/mL (3.09 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0927 mL	15.4636 mL	30.9272 mL
5 mM	0.6185 mL	3.0927 mL	6.1854 mL
10 mM	0.3093 mL	1.5464 mL	3.0927 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 20% HP-β-CD in Saline
Solubility: 12.5 mg/mL (38.66 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (252 KB) HNMR (248 KB) LCMS (258 KB)

Handling Instructions (2659 KB)

References

[1]. Li W, et al. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathway. Eur J Pharmacol. 2013 Sep 5;715(1-3):62-71. [Content Brief]

[2]. Li W, et al. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):21-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Acetone / DMSO / DMF	1 mM	3.0927 mL	15.4636 mL	30.9272 mL	77.3180 mL
DMSO / DMF	5 mM	0.6185 mL	3.0927 mL	6.1854 mL	15.4636 mL
DMF	10 mM	0.3093 mL	1.5464 mL	3.0927 mL	7.7318 mL

(±)-Stylopine Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(±)-Stylopine4312-32-7TetrahydrocoptisineParasiteCorydalisanti-parasiticalkaloidInhibitorinhibitorinhibit

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(±)-Stylopine (Synonyms: Tetrahydrocoptisine)

Customer Review

Other Forms of (±)-Stylopine:

(±)-Stylopine Related Antibodies

1 Publications Citing Use of MCE (±)-Stylopine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Parasite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

(±)-Stylopine Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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