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  4. Timonacic

Timonacic  (Synonyms: 1,3-Thiazolidine-4-carboxylic acid)

Cat. No.: HY-B1169 Purity: ≥98.0%
SDS
COA
Handling Instructions Technical Support

Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD50 of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer.

For research use only. We do not sell to patients.

Timonacic Chemical Structure

Timonacic Chemical Structure

CAS No. : 444-27-9

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10 mM * 1 mL in DMSO
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Timonacic:

Timonacic Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Timonacic (1,3-Thiazolidine-4-carboxylic acid) is an orally active thiol antioxidant. Timonacic has anti-aging and anti-hepatotoxic effects. Timonacic has a LD50 of 400 mg/kg for mice. Timonacic can be used in the research of liver diseases, gastrointestinal diseases, and cancer[1][2].

In Vitro

Timonacic can form a chelate with palladium(II) chloride in a buffered medium. Based on this, a spectrophotometric method has been developed to effectively determine its content. This method exhibits a good linear relationship, high precision, and accuracy, and is suitable for pharmaceutical quality control[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Timonacic Related Antibodies
In Vivo

Timonacic (25-60 mg/kg; 2 weeks) is well tolerated by dogs[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

133.17

Formula

C4H7NO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1NCSC1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 14.29 mg/mL (107.31 mM; ultrasonic and warming and heat to 60°C)

DMSO : 6 mg/mL (45.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.5092 mL 37.5460 mL 75.0920 mL
5 mM 1.5018 mL 7.5092 mL 15.0184 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

SDS (480 KB)

COA (249 KB) HNMR (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 7.5092 mL 37.5460 mL 75.0920 mL 187.7300 mL
5 mM 1.5018 mL 7.5092 mL 15.0184 mL 37.5460 mL
10 mM 0.7509 mL 3.7546 mL 7.5092 mL 18.7730 mL
15 mM 0.5006 mL 2.5031 mL 5.0061 mL 12.5153 mL
20 mM 0.3755 mL 1.8773 mL 3.7546 mL 9.3865 mL
25 mM 0.3004 mL 1.5018 mL 3.0037 mL 7.5092 mL
30 mM 0.2503 mL 1.2515 mL 2.5031 mL 6.2577 mL
40 mM 0.1877 mL 0.9386 mL 1.8773 mL 4.6932 mL
H2O 50 mM 0.1502 mL 0.7509 mL 1.5018 mL 3.7546 mL
60 mM 0.1252 mL 0.6258 mL 1.2515 mL 3.1288 mL
80 mM 0.0939 mL 0.4693 mL 0.9386 mL 2.3466 mL
100 mM 0.0751 mL 0.3755 mL 0.7509 mL 1.8773 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Timonacic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Timonacic444-27-91,3-Thiazolidine-4-carboxylic acidAmino Acid DerivativesAntioxidantanti-aginganti-hepatotoxicityInhibitorinhibitorinhibit

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