2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Tiodazosin

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

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Tiodazosin Chemical Structure

Tiodazosin Chemical Structure

CAS No. : 66969-81-1

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Tiodazosin Related Antibodies

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Description

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist.

IC50 & Target

alpha adrenergic receptor[1]
In Vitro

Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. In the mesenteric artery, Tiodazosin produces a parallel shift to the right in the concentration response curves to norepinephrine. A Schild plot constructed from two concentrations of Tiodazosin results in a pA2 value of 8.66 and a slope equal to -0.99. Tiodazosin inhibits contraction to norepinephrine in the portal vein and the inhibition results in a nonparallel inhibition of the norepinephrine concentration-response curve with a marked depression of maximal norepinephrine response[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tiodazosin Related Antibodies
Molecular Weight

431.47

Formula

C18H21N7O4S
CAS No.
SMILES

O=C(N1CCN(C2=NC(N)=C3C=C(OC)C(OC)=CC3=N2)CC1)C4=NN=C(SC)O4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Cell Assay
[1]

Arteries and portal veins isolated male Wistar rats (150 to 300 g) are sued and prepared for in vitro studies. Vessels are incubated with appropriate concentrations of Tiodazosin, prazosin or phentolamine for one hour. Contractile responses to norepinephrine or potassium chloride are then repeated in the presence of Tiodazosin[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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Tiodazosin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tiodazosin66969-81-1BL-5111BL5111BL 5111Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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