U91356

Cat. No.: HY-U00227: FAQs
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U91356 is a dopamine receptor agonist.

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U91356 Chemical Structure

CAS No. : 152886-85-6

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
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Description

U91356 is a dopamine receptor agonist.

IC₅₀ & Target

Dopamine receptor^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	111.2 nM Compound: 2	Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET assay Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET assay	[PMID: 28300398]
HEK293	EC₅₀	121.9 nM Compound: 2	Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed as induction of beta-arrestin 2 recruitment by BRET assay Agonist activity at renilla luciferase-tagged human dopamine D2 receptor expressed in HEK293 cells coexpressing mVenus-fused beta-arrestin 2 assessed as induction of beta-arrestin 2 recruitment by BRET assay	[PMID: 28300398]
HEK293	EC₅₀	17.1 nM Compound: 2	Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 by BRET assay Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused GalphaoA/GFP10-fused Ggamma2 by BRET assay	[PMID: 28300398]
HEK293	EC₅₀	9.1 nM Compound: 2	Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assay Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assay	[PMID: 28300398]
HEK-293T	EC₅₀	16 nM Compound: 13	Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assay Agonist activity at human D2 receptor transfected in HEK293T cells by BRET based G0 activation assay	[PMID: 27035329]
HEK-293T	EC₅₀	18.3 nM Compound: 13	Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assay Agonist activity at human D3 receptor transfected in HEK293T cells by BRET based G0 activation assay	[PMID: 27035329]

In Vivo

U91356 (U-91356) shows good dopaminergic agonist activity, and has good metabolic stability and oral bioavailability in the rat and monkey^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

231.29

Formula

C₁₃H₁₇N₃O

CAS No.

152886-85-6

SMILES

O=C1N2C3=C(C[C@@H](NCCC)C2)C=CC=C3N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kreiss DS, et al. Dopamine receptor agonist potencies for inhibition of cell firing correlate with dopamine D3receptor binding affinities. Eur J Pharmacol. 1995 Apr 24;277(2-3):209-14. [Content Brief]

[2]. Moon MW, et al. Medicinal chemistry of imidazoquinolinone dopamine receptor agonists. Drug Des Discov. 1993;9(3-4):313-22. [Content Brief]

U91356 Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U91356152886-85-6U 91356U-91356Dopamine ReceptorInhibitorinhibitorinhibit

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