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  5. Uric acid

Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.

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Uric acid Chemical Structure

Uric acid Chemical Structure

CAS No. : 69-93-2

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Customer Review

Based on 9 publication(s) in Google Scholar

Other Forms of Uric acid:

Uric acid Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Uric acid, scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Uric acid (400 μM; 48 hours) protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
? Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) is higher than that in cells treated with indomethacin alone. Uric acid has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uric acid Related Antibodies
In Vivo

Uric acid (250 mg/kg; p.o.) ameliorates indomethacin-induced enteropathy[2].
? Oral administration of uric acid decreased ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57BL/6J mice[2]
Dosage: 250 mg/kg body weight
Administration: P.o.
Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
Clinical Trial
Molecular Weight

168.11

Formula

C5H4N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)NC2=C(NC(N2)=O)C1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M NaOH : 8.33 mg/mL (49.55 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

H2O : 6.25 mg/mL (37.18 mM; ultrasonic and adjust pH to 10 with 1M NaOH)

DMSO : 0.67 mg/mL (3.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.9485 mL 29.7424 mL 59.4849 mL
5 mM 1.1897 mL 5.9485 mL 11.8970 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 10 mg/mL (59.48 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.96%

COA (249 KB) HNMR (263 KB) RP-HPLC (185 KB) MS (68 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O / 1M NaOH 1 mM 5.9485 mL 29.7424 mL 59.4849 mL 148.7122 mL
H2O / 1M NaOH 5 mM 1.1897 mL 5.9485 mL 11.8970 mL 29.7424 mL
10 mM 0.5948 mL 2.9742 mL 5.9485 mL 14.8712 mL
15 mM 0.3966 mL 1.9828 mL 3.9657 mL 9.9141 mL
20 mM 0.2974 mL 1.4871 mL 2.9742 mL 7.4356 mL
25 mM 0.2379 mL 1.1897 mL 2.3794 mL 5.9485 mL
30 mM 0.1983 mL 0.9914 mL 1.9828 mL 4.9571 mL
1M NaOH 40 mM 0.1487 mL 0.7436 mL 1.4871 mL 3.7178 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Uric acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uric acid69-93-2Reactive Oxygen SpeciesEndogenous Metabolitesingletoxygenperoxynitritelipidperoxidationantioxidantenteropathy oxidativestresscytotoxicityInhibitorinhibitorinhibit

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