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  5. Uric acid sodium

Uric acid sodium  (Synonyms: Monosodium urate)

Cat. No.: HY-B2130A Purity: 99.61%
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Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation.

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Uric acid sodium Chemical Structure

Uric acid sodium Chemical Structure

CAS No. : 1198-77-2

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Based on 9 publication(s) in Google Scholar

Other Forms of Uric acid sodium:

Uric acid sodium Related Antibodies

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Description

Uric acid sodium (Monosodium urate), scavenger of oxygen radical, is a very important antioxidant that help maintains the stability of blood pressure and antioxidant stress. Uric acid sodium can remove reactive oxygen species (ROS) such as singlet oxygen and peroxynitrite, inhibiting lipid peroxidation[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

In Vitro

Uric acid (400 μM; 48 hours) sodium protects Caco-2 cells from indomethacin-induced lipid peroxidation[2].
Co-treatment of cells with Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium significantly decreases ROS levels compared to those in cells incubated with indomethacin alone. Cell viability in Caco-2 cells treated with both Indomethacin and Uric acid (200 μM IND plus 400 μM UA; 24 hours) sodium is higher than that in cells treated with indomethacin alone. Uric acid sodium has a protective effect on indomethacin-induced intestinal cell changes through its antioxidant activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Uric acid sodium Related Antibodies
In Vivo

Uric acid (250 mg/kg; p.o.) sodium ameliorates indomethacin-induced enteropathy[2].
Oral administration of uric acid sodium decreases ROS accumulation in the ileum in a mouse model of indomethacin-induced enteropathy[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male C57BL/6J mice[2]
Dosage: 250 mg/kg body weight
Administration: P.o.
Result: When mice treated with indomethacin were concurrently administered uric acid orally, ulcer areas were significantly reduced, in a uric acid dose-dependent manner.
Clinical Trial
Molecular Weight

190.09

Formula

C5H3N4NaO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)NC2=C(N=C(O[Na])N2)C1=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

1M NaOH : 8.33 mg/mL (43.82 mM; ultrasonic and warming and adjust pH to 12 with 1M NaOH and heat to 60°C)

DMSO : 3.03 mg/mL (15.94 mM; ultrasonic and warming and adjust pH to 4 with 1 M HCL and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2607 mL 26.3033 mL 52.6067 mL
5 mM 1.0521 mL 5.2607 mL 10.5213 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC/saline water

    Solubility: 40 mg/mL (210.43 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.61%

SDS (393 KB)

COA (248 KB) RP-HPLC (208 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / 1M NaOH 1 mM 5.2607 mL 26.3033 mL 52.6067 mL 131.5167 mL
5 mM 1.0521 mL 5.2607 mL 10.5213 mL 26.3033 mL
10 mM 0.5261 mL 2.6303 mL 5.2607 mL 13.1517 mL
15 mM 0.3507 mL 1.7536 mL 3.5071 mL 8.7678 mL
1M NaOH 20 mM 0.2630 mL 1.3152 mL 2.6303 mL 6.5758 mL
25 mM 0.2104 mL 1.0521 mL 2.1043 mL 5.2607 mL
30 mM 0.1754 mL 0.8768 mL 1.7536 mL 4.3839 mL
40 mM 0.1315 mL 0.6576 mL 1.3152 mL 3.2879 mL
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Uric acid sodium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Uric acid1198-77-2Monosodium urateReactive Oxygen SpeciesEndogenous Metabolitesingletoxygenperoxynitritelipidperoxidationantioxidantenteropathy oxidativestresscytotoxicityInhibitorinhibitorinhibit

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