Zaurategrast ethyl ester sulfate (Synonyms: CDP323 sulfate; UCB1184197 sulfate)

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Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.

For research use only. We do not sell to patients.

Zaurategrast ethyl ester sulfate Chemical Structure

CAS No. : 1214261-78-5

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Other In-stock Forms of Zaurategrast ethyl ester sulfate:

Zaurategrast ethyl ester

Other Forms of Zaurategrast ethyl ester sulfate:

Zaurategrast In-stock
Zaurategrast ethyl ester In-stock

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•Related Small Molecules:

•Related Proteins:

View All Integrin Isoform Specific Products:

View All Isoforms

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

Biological Activity
Purity & Documentation
References
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Description

Zaurategrast ethyl ester sulfate (CDP323 sulfate), the ethyl ester proagent of CT7758^[1], is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders^[2].

IC₅₀ & Target

α4β1/α4β7 integrin^[1]

In Vitro

Zaurategrast ethyl ester sulfate (CDP323 sulfate), an ethyl ester prodrug of CT7758, shows some improvements in increasing mass transfer^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

647.54

Formula

C₂₈H₂₉BrN₄O₃.1/2H₂O₄S

CAS No.

1214261-78-5

SMILES

O=C(OCC)[C@H](CC1=CC=C(NC2=NC=CC3=C2C=NC=C3)C=C1)NC4=C(Br)C(C45CCCCC5)=O.O=S(O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Chanteux H, et al. Cross-Species Differences in the Preclinical Pharmacokinetics of CT7758, an α4β1/α4β7 Integrin Antagonist. Drug Metab Dispos. 2015 Sep;43(9):1381-91. [Content Brief]

[2]. Davenport RJ, et al. Alpha4-integrin antagonism--an effective approach for the treatment of inflammatory diseases? Drug Discov Today. 2007 Jul;12(13-14):569-76. [Content Brief]

Zaurategrast ethyl ester sulfate Related Classifications

Inflammation/Immunology

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zaurategrast ethyl ester1214261-78-5CDP323UCB1184197CDP 323CDP-323UCB 1184197UCB-1184197IntegrinInhibitorinhibitorinhibit

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